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Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers

   
@article{APS3586,
	author = {Márcio Gonçalves de SOUSA and Juan Carlos YUGAR-TOLEDO and Marcelo RUBIRA and Sílvia Elaine FERREIRA-MELO and Rodrigo PLENTZ and Deise BARBIERI and Fernanda CONSOLIM-COLOMBO and Maria Cláudia IRIGOYEN and Heitor MORENO Jr},
	title = {Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers},
	journal = {Acta Pharmacologica Sinica},
	volume = {26},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Aim: To compare the acute effects of ascorbic acid on vasodilation of veins and
arteries in vivo. Methods: Twenty-six healthy non-smokers and 23 healthy moderate
smokers were recruited in this study. The dorsal hand vein compliance technique
and flow-mediated dilation were used. Dose-response curves to bradykinin
and sodium nitroprusside were constructed to test the endothelium-dependent
and -independent relaxation before and after acute infusion of ascorbic acid.
Results: Smokers had an impaired venodilation with bradykinin compared with
non-smokers (68.3%±13.2% vs 93.7%±20.1%, respectively; P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3586}
}