@article{APS3564,
author = {Zhan-jun ZHANG and Zhong WANG and Xiao-yan ZHANG and Kang YING and Jian-xun LIU and Yong-yan WANG},
title = {Gene expression profile induced by oral administration of baicalin and gardenin after focal brain ischemia in rats},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {3},
year = {2016},
keywords = {},
abstract = {Aim: To investigate differential gene expression and the pharmacological mechanism
of baicalin and gardenin in focal cerebral ischemia in rats with high-density
cDNA microarray. Methods: Rat left middle cerebral arteries were occluded and
treated with either baicalin or gardenin. The pharmacological effects were investigated
using the difference in infarction areas before and after treatment, which
were determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Gene expression
was demonstrated using a “Biostar40S” gene microarray. Semiquantitative
reverse transcription-polymerase chain reaction (RT-PCR) was used to verify the
result of the selected genes. Results: Both baicalin and gardenin reduced the
infarction areas in focal cerebral ischemia rats (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3564}
}