@article{APS11196,
author = {Chen-ze Zhu and Gui-zhi Li and Hai-feng Lyu and Yang-yang Lu and Yue Li and Xiang-nan Zhang},
title = {Modulation of autophagy by melatonin and its receptors: implications in brain disorders},
journal = {Acta Pharmacologica Sinica},
volume = {46},
number = {3},
year = {2025},
keywords = {},
abstract = {Autophagy plays a crucial role in maintaining neuronal homeostasis and function, and its disruption is linked to various brain diseases. Melatonin, an endogenous hormone that primarily acts through MT1 and MT2 receptors, regulates autophagy via multiple pathways. Growing evidence indicates that melatonin’s ability to modulate autophagy provides therapeutic and preventive benefits in brain disorders, including neurodegenerative and affective diseases. In this review, we summarize the key mechanisms by which melatonin affects autophagy and explore its therapeutic potential in the treatment of brain disorders.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/11196}
}