@article{APS11097,
author = {Ming-ming Wang and Yue Zhao and Juan Liu and Rong-rong Fan and Yan-qing Tang and Zheng-yang Guo and Ting Li},
title = {The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases},
journal = {Acta Pharmacologica Sinica},
volume = {45},
number = {10},
year = {2024},
keywords = {},
abstract = {Pattern recognition receptors are an essential part of the immune system, which detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and help shape both innate and adaptive immune responses. When dsDNA is present, cyclic GMP-AMP Synthase (cGAS) produces a second messenger called cyclic GMP-AMP (cGAMP), which then triggers an adaptor protein called STING, and eventually activates the expression of type I interferon (IFN) and pro-inflammatory cytokines in immune cells. The cGAS-STING signaling pathway has been receiving a lot of attention lately as a key immune-surveillance mediator. In this review, we summarize the present circumstances of the cGAS-STING signaling pathway in viral infections and inflammatory diseases, as well as autoimmune diseases. Modulation of the cGAS-STING signaling pathway provides potential strategies for treating viral infections, inflammatory diseases, and autoimmune diseases.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/11097}
}