@article{APS10948,
author = {Si Gao and Xue-ping Liu and Ting-ting Li and Li Chen and Yi-ping Feng and Yu-kun Wang and Yan-jun Yin and Peter J. Little and Xiao-qian Wu and Suo-wen Xu and Xu-dong Jiang},
title = {Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery},
journal = {Acta Pharmacologica Sinica},
volume = {45},
number = {1},
year = {2023},
keywords = {},
abstract = {Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is escalating in prevalence worldwide. Despite accounting for over 50% of all HF patients, the mechanistic underpinnings driving HFpEF are poorly understood, thus impeding the discovery and development of mechanism-based therapies. HFpEF is a disease syndrome driven by diverse comorbidities, including hypertension, diabetes and obesity, pulmonary hypertension, aging, and atrial fibrillation. There is a lack of high-fidelity animal models that faithfully recapitulate the HFpEF phenotype, owing primarily to the disease heterogeneity, which has hampered our understanding of the complex pathophysiology of HFpEF. This review provides an updated overview of the currently available animal models of HFpEF and discusses their characteristics from the perspective of energy metabolism. Interventional strategies for efficiently utilizing energy substrates in preclinical HFpEF models are also discussed.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/10948}
}