@article{APS10902,
author = {Zhen-duo Zhu and Mei Zhang and Zhen Wang and Chun-ru Jiang and Chong-jian Huang and Hui-juan Cheng and Qiu-yun Guan and Tian-tian Su and Man-man Wang and Yi Gao and Hong-fei Wu and Wei Wei and Yong-sheng Han and Qing-tong Wang},
title = {Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis},
journal = {Acta Pharmacologica Sinica},
volume = {44},
number = {10},
year = {2023},
keywords = {},
abstract = {Patients with rheumatoid arthritis (RA) have a much higher incidence of cardiac dysfunction, which contributes to the high mortality rate of RA despite anti-arthritic drug therapy. In this study, we investigated dynamic changes in cardiac function in classic animal models of RA and examined the potential effectors of RA-induced heart failure (HF). Collagen-induced arthritis (CIA) models were established in rats and mice. The cardiac function of CIA animals was dynamically monitored using echocardiography and haemodynamics. We showed that cardiac diastolic and systolic dysfunction occurred in CIA animals and persisted after joint inflammation and that serum proinflammatory cytokine (IL-1β, TNF-α) levels were decreased. We did not find evidence of atherosclerosis (AS) in arthritic animals even though cardiomyopathy was significant. We observed that an impaired cardiac β1AR-excitation contraction coupling signal was accompanied by sustained increases in blood epinephrine levels in CIA rats. Furthermore, serum epinephrine concentrations were positively correlated with the heart failure biomarker NT-proBNP in RA patients (r2 = +0.53, P },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/10902}
}