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c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression

   
@article{APS10716,
	author = {Wen-die Wang and Yue Shang and Chen Wang and Jun Ni and Ai-min Wang and Gao-jie Li and Ling Su and Shu-zhen Chen},
	title = {c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression},
	journal = {Acta Pharmacologica Sinica},
	volume = {43},
	number = {11},
	year = {2022},
	keywords = {},
	abstract = {The forkhead box M1 (FoxM1) protein, a transcription factor, plays critical roles in regulating tumor growth and drug resistance, while cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, is involved in the ubiquitin–proteasome pathway. In this study, we investigated the effects of c-FLIP on the expression and ubiquitination levels of FoxM1 along with drug susceptibility in non-small-cell lung cancer (NSCLC) cells. We first showed that the expression levels of FoxM1 and c-FLIP were increased and positively correlated (R2 = 0.1106, P },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/10716}
}