@article{APS10551,
author = {Kristine Griffett and Matthew E. Hayes and Michael P. Boeckman and Thomas P. Burris},
title = {The role of REV-ERB in NASH},
journal = {Acta Pharmacologica Sinica},
volume = {43},
number = {5},
year = {2022},
keywords = {},
abstract = {REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBα and REV-ERBβ) is heme, and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes. These two receptors regulate a large range of physiological processes including several important in the pathophysiology of non-alcoholic steatohepatitis (NASH). These include carbohydrate and lipid metabolism as well as inflammatory pathways. A number of synthetic REV-ERB agonists have been developed as chemical tools and they show efficacy in animal models of NASH. Here, we will review the functions of REV-ERB with regard to their relevance to NASH as well as the potential to target REV-ERB for treatment of this disease.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/10551}
}