How to cite item

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation

   
@article{APS10289,
	author = {Yu-hang Zhang and Shu-xiang Cui and Sheng-biao Wan and Shu-hua Wu and Xian-jun Qu},
	title = {Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation},
	journal = {Acta Pharmacologica Sinica},
	volume = {42},
	number = {3},
	year = {2021},
	keywords = {},
	abstract = {Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated the role of S1PR2 internalization in 5-fluorouracil (5-FU) resistance in human colorectal cancer (CRC). Clinical data of randomly selected 60 CRC specimens showed the correlation between S1PR2 internalization and increased intracellular uracil (P },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/10289}
}