Vol 46, No 4 (April 2025): Acta Pharmacologica Sinica

Review Article

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling   Pages (795-804) Open
Zheng-Jie Chia, Hirushi Kumarapperuma, Ruizhi Zhang, Peter J. Little, Danielle Kamato
Multifaceted roles of UFMylation in health and disease   Pages (805-815)
Ru-na Wang, Lin Li, Jun Zhou, Jie Ran
Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential   Pages (816-828)
Jin Wu, Wan Xu, Ying Su, Guang-hui Wang, Jing-jing Ma
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease   Pages (829-835) Open
Wei Zhou, Hong-Yuan Chu
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology   Pages (836-851)
Zhi-yuan Guo, Xin Wu, Shui-juan Zhang, Jian-hua Yang, Hua Miao, Ying-yong Zhao

Article

A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia   Pages (852-866)
Wei Tang, Rong Cheng, Meng-yue Gao, Min-jin Hu, Lu Zhang, Qiang Wang, Xin-yu Li, Wei Yan, Xiao-ying Wang, Hai-mei Yang, Jian Cheng, Zi-chun Hua
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses   Pages (867-879)
Jing Cui, Xiao-ran Wang, Jie Yu, Bo-rui Zhang, Ya-fei Shi, Kwok-Fai So, Li Zhang, Ji-an Wei
Activation of glutamine synthetase (GS) as a new strategy for the treatment of major depressive disorder and other GS- related diseases   Pages (880-891) Open
Jae Soon Kang, Hwajin Kim, Ji Hyeong Baek, Miyoung Song, Hyeongchan Park, Wonjune Jeong, Hye Jin Chung, Dae Young Yoo, Dong Kun Lee, Sang Won Park, Hyun Joon Kim
The effects of diazepam on sleep depend on the photoperiod   Pages (892-903)
Maria Panagiotou, Johanna H. Meijer, Tom Deboer
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons   Pages (904-921)
Ou-Yang Zhanmu, Yang Yang, Bin Feng, Hong-yang Wang, Hao Li, Hui-juan Zhou, Wen-qiang Ge, Ke-xing Wan, Sui-xi Wang, Kai-ling Zhang, Hong Zhang, Lei Pei, Hui-lin Pan, Qing Tian, Man Li
Endothelial FOSL1 drives angiotensin II-induced myocardial injury via AT1R-upregulated MYH9   Pages (922-939)
Wen-jing Zhao, Yi Qian, Yi-feng Zhang, Ai-hua Yang, Jia-xin Cao, Hong-yan Qian, Yi Liu, Wei-zhong Zhu
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy   Pages (940-950)
Yang-yang Zheng, Dan-ning Shen, Xiao-lu Peng, Wen-qing San, Qian-you Zhou, Sheng-ju Yang, Guo-liang Meng, Jia-hai Shi, Yun Chen
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy   Pages (951-963)
Bu-chun Zhang, Wen-ya Zhu, Sheng-nan Wang, Meng-meng Zhu, Hui Ma, Liang Dong, Xiao-xiao Yang, Chuan-rui Ma, Li-kun Ma, Yuan-li Chen
SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation   Pages (964-975)
Hong Li, Ming-xia Peng, Rui-xue Yang, Jian-xing Chen, Yue-mei Wang, Pan-xia Wang, Yue-huai Hu, Di-yi Pan, Pei-qing Liu, Jing Lu
Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction   Pages (976-988)
Rui Ni, Xiao-yun Ji, Ting Cao, Xiu-wen Liu, Chao Wang, Chao Lu, Angel Peng, Zhu-xu Zhang, Guo-Chang Fan, Jin Zhang, Zhao-liang Su, Tian-qing Peng
Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy   Pages (989-1001)
Yue-qin Zhu, Li-li Wang, Zi-hao Li, Shi-shun Qian, Zhou Xu, Jin Zhang, Yong-hu Song, Xue-sheng Pan, Na Du, Amira Abou-Elnour, Lynn Jia Tay, Jing-rong Zhang, Meng-xue Li, Yu-xian Shen, Yan Huang
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells   Pages (1002-1015)
Jing Li, Li-ting Chen, You-liang Wang, Mei-xia Kang, Shi-ting Liang, Xi-zhen Hong, Fan Fan Hou, Fu-jian Zhang
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation   Pages (1016-1029)
Le-jin Yan, Shuang Qi, Chao Wu, Rui Jin, Chen Hu, Ao-li Wang, Bei-lei Wang, Hong-wei Yu, Li Wang, Jing Liu, Zi-ping Qi, Wen-chao Wang, Qing-song Liu
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy   Pages (1030-1044) Open
Yu Wei, Ming-ming Sun, Rui-li Zhang, Lin Wang, Li-hong Yang, Chang-liang Shan, Jian-ping Lin
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis   Pages (1045-1057)
Yue-kang Li, Fu-jing Ge, Xiang-ning Liu, Chen-ming Zeng, Mei-jia Qian, Yong-hao Li, Ming-ming Zheng, Jing-jing Qu, Liang-jie Fang, Jin-jian Lu, Bo Yang, Qiao-jun He, Jian-ya Zhou, Hong Zhu
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy   Pages (1058-1067)
Ming-ming Zheng, Jia-yi Li, Hong-jie Guo, Jie Zhang, Long-sheng Wang, Ke-fan Jiang, Hong-hai Wu, Qiao-jun He, Ling Ding, Bo Yang
RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33   Pages (1068-1081)
Cheng-piao Lu, Jia-bin Li, Dong-bao Li, Yu-hong Wang, Xiao-gang Jiang, Jing-jing Ma, Guoqiang Xu
The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer   Pages (1082-1096)
Qiu-yun Luo, Jing Yang, Tian Di, Zeng-fei Xia, Lin Zhang, Wen-tao Pan, Shan Shi, Li-qiong Yang, Jian Sun, Miao-zhen Qiu, Da-jun Yang
STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer   Pages (1097-1110)
Jun Wang, Hui-min Zhang, Guan-hua Zhu, Li-li Zhao, Ji Shi, Zhou-tong Dai, Jia-peng Li, Xing-rui Li, Fan Sun, Yuan Wu, Shao-yong Chen, Han-ning Li, Xing-hua Liao, Yuan Xiang
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors   Pages (1111-1122)
Xin-heng He, Jun-rui Li, Shi-yi Shen, H. Eric Xu
Combined in silico/in vitro approaches for identifying modulators of the activity of the p.Tyr110Cys Carnitine O-Acetyltransferase (CRAT) variant associated to an early onset case of Leigh syndrome   Pages (1123-1136)
Lucas Cafferati Beltrame, Maria Noemi Sgobba, Luna Laera, Valeria Scaglione, Sabino Todisco, Serena Barile, Anna Lucia Francavilla, Danila Imperia De Luca, Michele Montaruli, Vito Porcelli, Lorenzo Guerra, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri

Brief Communication

SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)   Pages (1137-1144)
Bing-ling Zhong, Yi-fei Zhang, Hao-yi Zheng, Qiang Chen, Hua-dong Lu, Xiu-ping Chen