Vol 46, No 1 (January 2025): Acta Pharmacologica Sinica

Review Article

Targeted degradation of membrane and extracellular proteins with LYTACs   Pages (1-7)
Yu-yang Li, Yang Yang, Ren-shuai Zhang, Rui-xin Ge, Song-bo Xie
Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential   Pages (8-32)
Ting-ting Xu, Ying-yi Deng, Xi-yong Yu, Min Li, Yuan-yuan Fu

Article

BNIP3-mediated mitophagy attenuates hypoxic–ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62–KEAP1–NRF2 pathway activation to maintain iron and redox homeostasis   Pages (33-51)
Xin-xin Wang, Mei Li, Xiao-wen Xu, Wen-bin Zhao, Yi-ming Jin, Li-li Li, Zheng-hong Qin, Rui Sheng, Hong Ni
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration   Pages (52-65)
Jia-qi He, Ruo-lan Yuan, Yu-tong Jiang, Ye Peng, Jun-rui Ye, Sha-sha Wang, Li-qing Li, Yuan Ruan, Pei-yi Li, Xu Yan, Wen-bin He, Gang Li, Shi-feng Chu, Zhao Zhang, Nai-hong Chen
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway   Pages (66-80)
Zhuo-hui Luo, Jiang-shan Guo, Shuo Pang, Wei Dong, Jia-xin Ma, Li Zhang, Xiao-long Qi, Fei-fei Guan, Shan Gao, Xiang Gao, Ning Liu, Shuo Pan, Wei Chen, Xu Zhang, Lian-feng Zhang ✉, Ya-jun Yang
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis   Pages (81-95)
Lin Wu, Li-tao Wang, Yu-xin Du, Ying-mei Zhang, Jun Ren
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway   Pages (96-106)
Hong-qin Yang, Zhi-wei Li, Xi-xi Dong, Jia-xin Zhang, Jin Shan, Min-jie Wang, Jing Yang, Min-hui Li, Jing Wang, Hong-mei Zhao
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A   Pages (107-121)
Tong Zhao, Zhi-ruo Zhou, Hui-qi Wan, Tian Feng, Xu-hui Hu, Xiao-qian Li, Shi-mei Zhao, Hong-lin Li, Ji-wei Hou, Wei Li, Da-yun Lu, Min-yi Qian, Xu Shen
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice   Pages (122-133)
Bi-xi Tang, Yong Zhang, Dan-dan Sun, Qin-yi Liu, Cong Li, Pei-pei Wang, Li-xin Gao, Xue-mei Zhang, Jia Li, Wei-liang Zhu, Yi Zang
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease   Pages (134-146)
Yu-xin Zhao, Ying-yin Sun, Liang-yun Li, Xiao-feng Li, Hai-di Li, Xin Chen, Ran Xia, Ying-li Yang, Xin-yu Jiang, Long-quan Zuo, Xiao-ming Meng, Hua Wang, Cheng Huang, Jun Li
Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis   Pages (147-158)
Hang-fei Liang, Xiao Yang, Hui-lin Li, Xuan Li, Jia-ning Tian, Hai-guo Su, Min Huang, Jian-hong Fang, Hui-chang Bi
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation   Pages (159-170)
Xin Wang, Xin Xie, Jia-yun Ni, Jing-yao Li, Xi-ang Sun, Hong-yan Xie, Ning-hao Yang, Heng-jiang Guo, Li Lu, Ming Ning, Li Zhou, Jun Liu, Chen Xu, Wei Zhang, Yi Wen, Qian Shen, Hong Xu, Li-min Lu
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice   Pages (171-183) Open
Alej, ro Serrano, Noelia Casares, Iñaki F. Trocóniz, Teresa Lozano, Juan J. Lasarte, Sara Zalba, María J. Garrido
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer   Pages (184-195)
Zi-yang Liu, Ya-wen Zhang, Hai-xia Zhuang, Yu-jie Ou, Qiu-yun Jiang, Ping-fei Li, Yuan-ming He, Ying Ren, Xin-liang Mao
Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential   Pages (196-207)
Shou-mao Shen, Dan-dan Yu, Lin-mao Ke, Li-gong Yao, Ming-zhi Su, Yue-wei Guo
Aristolochic acids-hijacked p53 promotes liver cancer cell growth by inhibiting ferroptosis   Pages (208-221)
Chun-yu Hou, Yu-hong Suo, Pan Lv, Hong-feng Yuan, Li-na Zhao, Yu-fei Wang, Hui-hui Zhang, Jiao Sun, Lin-lin Sun, Wei Lu, Ning-ning Zhang, Guang Yang, Xiao-dong Zhang
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10   Pages (222-230) Open
Enikő Major, Kuan-Hung Lin, Sue Chin Lee, Krisztina Káldi, Balázs Győrffy, Gábor J. Tigyi, Zoltán Benyó

Correction

Author Correction: c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression   Pages (231-232)
Wen-die Wang, Yue Shang, Chen Wang, Jun Ni, Ai-min Wang, Gao-jie Li, Ling Su, Shu-zhen Chen
Author Correction: Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes   Pages (233)
Shuang Guo, Xiang-wen Meng, Xiao-song Yang, Xiu-fen Liu, Chang-han Ou-Yang, Chao Liu

Author Correction

Author Correction: Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b   Pages (234)
Jian-jun Zhang, Xiao-hui Zhou, Yan Zhou, Yong-gang Wang, Bin-zhi Qian, Ai-na He, Zan Shen, Hai-yan Hu, Yang Yao