Vol 46, No 2 (February 2025): Acta Pharmacologica Sinica

Review Article

Overview and limitations of database in global traditional medicines: A narrative review   Pages (235-263)
Xiao-lan Li, Jian-qing Zhang, Xuan-jing Shen, Yu Zhang, De-an Guo
Cyclic GMP-AMP synthase recognizes the physical features of DNA   Pages (264-270)
Ling Dong, Yue-ru Hou, Na Xu, Xiao-qian Gao, Zhen Sun, Qing-kai Yang, Li-na Wang
The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca2+ transport in the pathogenesis of diseases   Pages (271-291)
Wen-bin Zhao, Rui Sheng

Article

VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke   Pages (292-307)
Shuai Wang, Yi Guo, Rui-qi Cao, Yong-ming Zhu, Shi-gang Qiao, Hua-ping Du, Yuan Liu, Yuan Xu, Xian-yong Zhou, Lei Sun, Qi-xia Lu, Ingmar Schoen, Hui-ling Zhang
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle   Pages (308-325)
Sha-sha Wang, Ye Peng, Ping-long Fan, Jun-rui Ye, Wen-yu Ma, Qing-lin Wu, Hong-yun Wang, Ya-juan Tian, Wen-bin He, Xu Yan, Zhao Zhang, Shi-feng Chu, Nai-hong Chen
Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1   Pages (326-337)
Peng-xi Deng, Marta Silva, Na Yang, Qing Wang, Xin Meng, Ke-qiang Ye, Hong-chang Gao, Wen-hua Zheng
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice   Pages (338-352)
Jun-qiang Zhao, Bing-yan Feng, Zhen-li Ye, Xiao-yin Ma, Jing-zhi Du, Jun-mei Li, Wan-liu Wu, Jing-jing Gao, Song-ji Li, Shi-yong Peng, Ji-sen Huai, Li-hao Ge, Cheng-biao Lu
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice   Pages (353-365)
Ya-nan Gao, Kai-jun Pan, Yong-mei Zhang, Ying-bei Qi, Wen-gang Chen, Ting Zhou, Hai-chao Zong, Hao-ran Guo, Jin-wen Zhao, Xing-chen Liu, Zi-tong Cao, Ze Chen, Tao Yin, Yi Zang, Jia Li
Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade   Pages (366-379)
Li-xia Du, Xin-yi Gao, Xue-qi Ren, Ya-yue Yang, Yang-yang Ding, Ao Xu, Xiao-yu Wang, Yu-xin Zhang, Shi Shu, Yu-fang Yang, Wen-li Mi, Zhi-fei Wang
Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration   Pages (380-392)
Yi-ting Yang, Ming-rui Ji, Zi-jin Lin, Ping Li, Run-ze Wu, Xiao-dong Liu, Li Liu
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates   Pages (393-403)
Kai Liao, Jia-hui Chen, Jie Ma, Chen-chen Dong, Chun-yang Bi, Ya-biao Gao, Yuan-fang Jiang, Tao Wang, Hui-yi Wei, Lu Hou, Jun-qi Hu, Jun-jie Wei, Chun-yuan Zeng, Yin-long Li, Sen Yan, Hao Xu, Steven H. Liang, Lu Wang
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish   Pages (404-415)
Yu-lai Liang, Yang-xi Hu, Fang-fang Li, Hong-min You, Jian Chen, Chun Liang, Zhi-fu Guo, Qing Jing
Oral administration of astilbin mitigates acetaminophen- induced acute liver injury in mice by modulating the gut microbiota   Pages (416-429)
Qin Yang, Wen-hao He, Li Xie, Tao Chen, Ruo-fan Liu, Jia-jia Hu, Jia-yin Guo, Guo-zhu Tan, Fu-ling Wu, Peng Gu, Peng Chen, Yu Chen
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages   Pages (430-447)
Yi-ping You, Liang Yan, Hua-yu Ke, Ya-ping Li, Zi-jian Shi, Zhi-ya Zhou, Hai-yan Yang, Tao Yuan, Ying-qing Gan, Na Lu, Li-hui Xu, Bo Hu, Dong-yun Ou-Yang, Qing-bing Zha, Xian-hui He
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling   Pages (448-461)
Fang-lin Li, Long-hua Gu, Yong-liang Tong, Run-qiu Chen, Shi-yi Chen, Xiao-lu Yu, Nan Liu, Jiang-ling Lu, Yuan Si, Jian-hua Sun, Jing Chen, Yi-ru Long, Li-kun Gong
Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia   Pages (462-473)
Xue-jing Shao, Wei Wang, Ai-xiao Xu, Xiao-tian Qi, Min-yi Cai, Wen-xin Du, Ji Cao, Qiao-jun He, Mei-dan Ying, Bo Yang
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner   Pages (474-488)
Fa-liang Xing, Bo-rui Li, Ying-jin Fang, Chen Liang, Jiang Liu, Wei Wang, Jin Xu, Xian-jun Yu, Yi Qin, Bo Zhang
19F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans   Pages (489-499)
Ze-yu Wang, Yong-mei Ren, Shu-wei Hu, Nai-xia Zhang, Meng-xiao Dong, Yun Li, Yang Yang, Zi-jia Guo, Shan-sen Xu, Jia Chen, Aik Han Goh, Xiao-yan Chen
Exploring the constitutive activation mechanism of the class A orphan GPR20   Pages (500-511)
Ming-yang Zhang, Jian-yang Ao, Ning Liu, Ting Chen, Shao-yong Lu

Correction

Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells   Pages (512-514)
Yin-da Qiu, Qi Yan, Yi Wang, Yan-fei Ye, Yan Wang, Meng-ying Wang, Pei-pei Wang, Shu-yuan Zhang, Da-long Wang, Hao Yan, Jing Ruan, Yun-jie Zhao, Le-hao Huang, Namki Cho, Kun Wang, Xiao-hui Zheng, Zhi-guo Liu