Vol 45, No 12 (December 2025): Acta Pharmacologica Sinica

Review Article

Immunocyte membrane-derived biomimetic nano-drug delivery system: a pioneering platform for tumour immunotherapy   Pages (2455-2473)
Yuan-ye Zeng, Qing Gu, Dan Li, Ai-xue Li, Rong-mei Liu, Jian-ying Liang, Ji-yong Liu

Article

Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats   Pages (2487-2496)
Yi-ting Du, Zhi-guang Pan, Bin-chi Chen, Feng-yan Sun
Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling   Pages (2474-2486)
Zhi-chao Xi, Han-gui Ren, Lin Ai, Yuan Wang, Meng-fan Liu, Yu-fei Qiu, Ji-ling Feng, Wang Fu, Qian-qian Bi, Feng Wang, Hong-xi Xu
ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model   Pages (2497-2512)
Xian-hua Deng, Xing-yang Liu, Yi-hua Wei, Ke Wang, Jun-rong Zhu, Jia-jun Zhong, Jing-yuan Zheng, Rui Guo, Yi-fan Zhu, Qiu-hong Ye, Meng-dan Wang, Ying-jie Chen, Jian-quan He, Ze-xu Chen, Shu-qiong Huang, Chong-shan Lv, Guo-qing Zheng, Sui-feng Liu, Lei Wen
Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation   Pages (2513-2526)
Xian-xi Ye, Qiao-ying Jiang, Meng-jun Wu, Qing-huai Ye, Hong Zheng
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation   Pages (2527-2539)
Ying Yang, Na Suo, Shi-hao Cui, Xuan Wu, Xin-yue Ren, Yin Liu, Ren Guo, Xin Xie
In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury   Pages (2540-2552)
Cong-ting Guo, Blake D. Jardin, Jun-sen Lin, Rachelle L. Ambroise, Ze Wang, Lu-zi Yang, Neil Mazumdar, Fu-jian Lu, Qing Ma, Yang-po Cao, Can-zhao Liu, Kai-long Li, Xu-jie Liu, Feng Lan, Ming-ming Zhao, Han Xiao, Er-dan Dong, William T. Pu, Yu-xuan Guo
DLK1 promoted ischemic angiogenesis through notch1 signaling in endothelial progenitor cells   Pages (2553-2566)
Ya-yu You, Ning Zhang, Zhuo Wang, Zhe-hui Yin, Qin-yi Bao, Shu-xin Lei, Xiao-jie Xie
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway   Pages (2567-2578)
Yan-lu Han, Teng-teng Yan, Hua-xin Li, Sha-sha Chen, Zhen-zhen Zhang, Meng-yao Wang, Mei-jie Chen, Yuan-li Chen, Xiao-xiao Yang, Ling-ling Wei, Ya-jun Duan, Shuang Zhang
SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization   Pages (2579-2597) Open
Xia-fang Lin, Xiao-na Cui, Jin Yang, Ya-fei Jiang, Tian-jiao Wei, Li Xia, Xin-yue Liao, Fei Li, Dan-dan Wang, Jian Li, Qi Wu, De-shan Yin, Yun-yi Le, Kun Yang, Rui Wei, Tian-pei Hong
Chromodomain Y‐like (CDYL) inhibition ameliorates acute kidney injury in mice by regulating tubular pyroptosis   Pages (2598-2610)
Ting Xiang, Ling-zhi Li, Jin-xi Li, Xin-yun Chen, Fan Guo, Jing Liu, Yi-ting Wu, Lin Lin, Rui-han Xu, Hui-ping Wang, Liang Ma, Ping Fu
G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren’s syndrome   Pages (2611-2624)
Ru-hong Fang, Zheng-wei Zhou, Rui Chu, Qiu-yun Guan, Feng He, Ming-li Ge, Pai-pai Guo, Hua-xun Wu, Ling-li Yao, Wei Wei, Yang Ma, Qing-tong Wang
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth   Pages (2625-2645)
Xue Wang, Qian-qian Li, Yan-xin Tang, Ye Li, Lu Zhang, Fei-fei Xu, Xue-li Fu, Kai Ye, Jia-qi Ma, Shi-man Guo, Fang-yuan Ma, Zhi-yu Liu, Xu-he Shi, Xian-meng Li, Hui-min Sun, Yue Wu, Wei-ying Zhang, Li-hong Ye
Recombinant human adenovirus type 5 promotes anti-tumor immunity via inducing pyroptosis in tumor endothelial cells   Pages (2646-2656)
Zhi-ming Wang, Meng-kai Li, Qing-ling Yang, Shi-xin Duan, Xin-yi Lou, Xin-yi Yang, Ying Liu, Yu-wen Zhong, Yu Qiao, Zi-shu Wang, Lei Sun, Feng Qian
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module   Pages (2657-2671)
Xiao-ju Shen, Hui-lan Wei, Xiao-cheng Mo, Xiao-xiang Mo, Li Li, Jing-chuan He, Xin-yu Wei, Xiao-jun Qin, Shang-ping Xing, Zhuo Luo, Zhi-quan Chen, Jie Yang
Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis   Pages (2672-2683)
Jing-nan Zhang, Ze Zhang, Zhen-lin Huang, Qian Guo, Ze-qi Wu, Chuang Ke, Bin Lu, Zheng-tao Wang, Li-li Ji

Correction

Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1   Pages (2684)
Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang, Su-ping Chen, Yang Zhang, Qing Liu, Liang Zhou, Xiao-gang Jiang, Kifayat Ullah, Qing Guo, Zhao-hui Liu, Ying Xu, Jun-hai Han, Jiajie Hou, Darran P O’Connor, Guoqiang Xu