Vol 45, No 10 (October 2024): Acta Pharmacologica Sinica

Review Article

The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases   Pages (1997-2010)
Ming-ming Wang, Yue Zhao, Juan Liu, Rong-rong Fan, Yan-qing Tang, Zheng-yang Guo, Ting Li
Targeting metabolism to enhance immunotherapy within tumor microenvironment   Pages (2011-2022)
Xiao-hui Liang, Xin-yi Chen, Yue Yan, Ao-yu Cheng, Jia-yi Lin, Yi-xin Jiang, Hong-zhuan Chen, Jin-mei Jin, Xin Luan

Perspective

Endothelial dysfunction: mechanisms and contribution to diseases   Pages (2023-2031)
Amir Ajoolabady, Domenico Pratico, Jun Ren

Article

Hepatic kynurenic acid mediates phosphorylation of Nogo-A in the medial prefrontal cortex to regulate chronic stress-induced anxiety-like behaviors in mice   Pages (2032-2044)
Lan Yan, Wen-jing Wang, Tong Cheng, Di-ran Yang, Ya-jie Wang, Yang-ze Wang, Feng-zhen Yang, Kwok-Fai So, Li Zhang
Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice   Pages (2045-2060)
Yong-sheng Zhou, Hao-bo Tao, Si-si Lv, Ke-qin Liang, Wen-yi Shi, Ke-yi Liu, Yun-yun Li, Lv-yi Chen, Ling Zhou, Shi-jin Yin, Qian-ru Zhao
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice   Pages (2061-2076)
Jian Lu, Xue-jian Zhao, Yuan Ruan, Xiao-jing Liu, Xuan Di, Rui Xu, Jia-ying Wang, Min-yi Qian, Hong-ming Jin, Wen-jun Li, Xu Shen
ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis   Pages (2077-2091)
Le-le Wang, Huan Wang, Si-jin Lin, Xing-yu Xu, Wen-juan Hu, Jia Liu, Hai-yan Zhang
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway   Pages (2092-2106)
Dong-ni Ji, Sai-di Jin, Yuan Jiang, Fei-yong Xu, Shu-wei Fan, Yi-lin Zhao, Xin-qi Liu, Hao Sun, Wen-zheng Cheng, Xin-yue Zhang, Xiao-xiang Guan, Bo-wen Zhang, Zhi-min Du, Ying Wang, Ning Wang, Rong Zhang, Ming-yu Zhang, Chao-qian Xu
THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation   Pages (2107-2118)
Heng-hui Xu, Sheng-xin Hao, He-yang Sun, Xin-xin Dong, Yuan Lin, Han Lou, Li-min Zhao, Ping-ping Tang, Zi-jia Dou, Jing-jing Han, Meng-han Du, Zhou-xiu Chen, Philipp Kopylov, Dmitry Shchekochikhin, Xin Liu, Yong Zhang
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis   Pages (2119-2133)
Wei-zhi Wang, Chao Liu, Jin-que Luo, Li-juan Lei, Ming-hua Chen, Yu-yan Zhang, Ren Sheng, Yi-ning Li, Li Wang, Xin-hai Jiang, Tong-mei Xiao, Yu-hao Zhang, Shun-wang Li, Ye-xiang Wu, Yang Xu, Yan-ni Xu, Shu-yi Si
A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles   Pages (2134-2148)
Kai Sun, Nan-lin Zhu, Su-ling Huang, Hui Qu, Yi-pei Gu, Li Qin, Jia Liu, Ying Leng
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence   Pages (2149-2162)
Ya-bing Xiong, Wen-yan Huang, Xian Ling, Shan Zhou, Xiao-xu Wang, Xiao-long Li, Li-li Zhou
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas   Pages (2163-2173)
Pei-ran Song, Zhi-peng Wan, Ge-ge Huang, Zi-lan Song, Tao Zhang, Lin-jiang Tong, Yan Fang, Hao-tian Tang, Yu Xue, Zheng-sheng Zhan, Fang Feng, Yan Li, Wen-hao Shi, Yu-qing Huang, Yi Chen, Wen-hu Duan, Jian Ding, Ao Zhang, Hua Xie
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects   Pages (2174-2185)
Ming-shi Xu, Xiao-fan Gu, Cong Li, Li-xuan Pan, Zi-xia Zhu, Meng Fan, Yun Zhao, Jian-fang Chen, Xuan Liu, Xiong-wen Zhang
T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin   Pages (2186-2198)
Jun-jun Liu, Zhi-di Pan, Ya-li Yue, Shu-sheng Wang, Jie Chen, Hua Jiang, Bao-hong Zhang, Ming-yuan Wu, Yun-sheng Yuan, Yan-lin Bian, Hai-yang Yin, Lei Wang, Jun-yan Li, John Gilly, Yue-qing Xie, Jian-wei Zhu
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods   Pages (2199-2211)
Fei Pan, Cheng-nuo Wang, Zhuo-hang Yu, Zeng-rui Wu, Ze Wang, Shang Lou, Wei-hua Li, Gui-xia Liu, Ting Li, Yu-zheng Zhao, Yun Tang
Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer: a pooled pharmacometrics analysis   Pages (2212-2225)
Hao-ran Dai, Yang Yang, Chen-yu Wang, Yue-ting Chen, Yi-fan Cui, Pei-jing Li, Jia Chen, Chen Yang, Zheng Jiao

Correction

Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis   Pages (2226-2227)
Xiang-jin Zheng, Wen-lin Chen, Jie Yi, Wan Li, Jin-yi Liu, Wei-qi Fu, Li-wen Ren, Sha Li, Bin-bin Ge, Yi-hui Yang, Yi-zhi Zhang, Hong Yang, Guan-hua Du, Yu Wang, Jin-hua Wang
Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways   Pages (2228)
Qi-wen Han, Qian-hang Shao, Xiao-tong Wang, Kai-li Ma, Nai-hong Chen, Yu-he Yuan