Vol 45, No 9 (September 2024): Acta Pharmacologica Sinica

Review Article

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis   Pages (1765-1776)
Ana Beatriz Santos, Andreia Carona, Miren Ettcheto, Antoni Camins, Amílcar Falcão, Ana Fortuna, Joana Bicker
Insomnia-related rodent models in drug discovery   Pages (1777-1792)
Ze-ka Chen, Yuan-yuan Liu, Ji-chuan Zhou, Gui-hai Chen, Chun-feng Liu, Wei-min Qu, Zhi-li Huang

Article

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1   Pages (1793-1808)
Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang, Su-ping Chen, Yang Zhang, Qing Liu, Liang Zhou, Xiao-gang Jiang, Kifayat Ullah, Qing Guo, Zhao-hui Liu, Ying Xu, Jun-hai Han, Jiajie Hou, Darran P O’Connor, Guoqiang Xu
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy   Pages (1809-1820)
Xiao-lu Jiang, Zu-bin Zhang, Chen-xi Feng, Chen-jie Lin, Hui Yang, Lan-lan Tan, Xin Ding, Li-xiao Xu, Gen Li, Tao Pan, Zheng-hong Qin, Bin Sun, Xing Feng, Mei Li
Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice   Pages (1821-1831)
Hua-shan Gong, Jing-pei Pan, Fei Guo, Mei-mei Wu, Li Dong, Yang Li, Wei-fang Rong
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats   Pages (1832-1847)
Jian-hui Xu, Tian-hui He, Nan-ping Wang, Wen-min Gao, Yong-jing Cheng, Qiao-feng Ji, Si-hao Wu, Yan-lin Wei, Yu Tang, Wen Z. Yang, Jie Zhang
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway   Pages (1848-1860)
Feng-ting Lu, Cheng-cui Huang, Wen-yi Lai, Gui-yong Yang, Zhu-jun Liang, Zi-yi Zhang, Tanvi Chokshi, Kai-min Guo, Yu-bo Tang, Yuan Chen, Zhong-han Yang, Si-jia Liang, Rui-ping Pang, Jia-guo Zhou, Yong-yuan Guan, Xiao-fei Lv, Ming-ming Ma
Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation   Pages (1861-1878) Open
Xiu-chun Li, Xia-yan Zhu, Yang-yue Wang, Shuo-lan Tong, Zhi-li Chen, Zi-yi Lu, Jian-hao Zhang, Lan-lan Song, Xing-hong Wang, Chi Zhang, Yi-han Sun, Chu-yue Zhong, Li-huang Su, Liang-xing Wang, Xiao-ying Huang
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol   Pages (1879-1897)
Zhi-hua Zheng, Jiao-jiao Wang, Jiu-guo Lin, Wei-le Ye, Jia-mi Zou, Li-yin Liang, Ping-lian Yang, Wan-lu Qiu, Yuan-yuan Li, Si-jia Yang, Man Zhao, Qing Zhou, Cheng-zhi Li, Min Li, Zhuo-ming Li, Dong-mei Zhang, Pei-qing Liu, Zhi-ping Liu
Restoration of HMGCS2-mediated ketogenesis alleviates tacrolimus-induced hepatic lipid metabolism disorder   Pages (1898-1911)
Sen-lin Li, Hong Zhou, Jia Liu, Jian Yang, Li Jiang, Hui-min Yuan, Meng-heng Wang, Ke-shan Yang, Ming Xiang
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages   Pages (1912-1925)
Mo-ting Liu, Yao Zhang, Cai-gui Xiang, Tao Yang, Xiao-han Wang, Qiu-kai Lu, Hui-min Lu, Chen Fan, Chun-lan Feng, Xiao-qian Yang, Duo-wu Zou, Heng Li, Wei Tang
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation   Pages (1926-1936)
Ya-qi Yang, Yi-jun Liu, Wen-xuan Qiao, Wei Jin, Shun-wei Zhu, Yu-xi Yan, Qiong Luo, Qiang Xu
GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma   Pages (1937-1950)
Rui-xin Sun, Yi-fan Liu, Yan-sha Sun, Min Zhou, Yi Wang, Bi-zhi Shi, Hua Jiang, Zong-hai Li
Bevacizumab induces ferroptosis and enhances CD8+ T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9   Pages (1951-1963)
Chun-yu Hou, Pan Lv, Hong-feng Yuan, Li-na Zhao, Yu-fei Wang, Hui-hui Zhang, Guang Yang, Xiao-dong Zhang
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer   Pages (1964-1977)
Xi-shan Wu, Xiao-yu Luo, Cheng-chang Li, Xiao-fan Zhao, Cheng Zhang, Xiao-shan Chen, Zhi-fang Lu, Tong Wu, Hao-nan Yu, Chao Peng, Qing-qing Hu, Hui Shen, Yong Xu, Yan Zhang
A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model   Pages (1978-1991)
Xin-yue Wang, Xin Chai, Lu-hu Shan, Xiao-hong Xu, Lei Xu, Ting-jun Hou, Hui-yong Sun, Dan Li

Correction

Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance   Pages (1992-1994)
Xiao-dan Guo, Guang-long Sun, Ting-ting Zhou, Xin Xu, Zhi-yuan Zhu, Vatcharin Rukachaisirikul, Li-hong Hu, Xu Shen
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway   Pages (1995-1996)
Shi-feng Chu, Zhao Zhang, Xin Zhou, Wen-bin He, Chen Chen, Piao Luo, Dan-dan Liu, Qi-di Ai, Hai-fan Gong, Zhen-zhen Wang, Hong-shuo Sun, Zhong-ping Feng, Nai-hong Chen