Vol 45, No 8 (August 2024): Acta Pharmacologica Sinica

Review Article

Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy   Pages (1533-1555)
Xuan Ni, Cheng-piao Lu, Guo-qiang Xu, Jing-jing Ma
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers   Pages (1556-1570)
Hui-yu Liu, Xiao-jiao Sun, Si-yu Xiu, Xiang-yu Zhang, Zhi-qi Wang, Yan-lun Gu, Chu-xiao Yi, Jun-yan Liu, Yu-song Dai, Xia Yuan, Hua-peng Liao, Zhen-ming Liu, Xiao-cong Pang, Tian-cheng Li
Liver receptor homolog-1: structures, related diseases, and drug discovery   Pages (1571-1581)
Tong Wu, Zhi-fang Lu, Hao-nan Yu, Xi-shan Wu, Yang Liu, Yong Xu

Article

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator   Pages (1582-1590)
Gu-fang Zhang, Kai-lian Zhu, Qi Li, Yue Zhang, John L. Waddington, Xiang-dong Du, Xue-chu Zhen
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder   Pages (1591-1603) Open
Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, Paula Perez-Pardo
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway   Pages (1604-1617)
Xia-yun Ni, Xiao-jun Feng, Zhi-hua Wang, Yang Zhang, Peter J. Little, Yang Cao, Suo-wen Xu, Li-qin Tang, Jian-ping Weng
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin   Pages (1618-1631)
Wan-te Lin, Yu-cheng Jiang, Yi-lin Mei, Yang-hao Chen, Zhao-zheng Zheng, Xue Han, Gao-jun Wu, Wei-jian Huang, Bo-zhi Ye, Guang Liang
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR   Pages (1632-1643)
Jin-feng Cai, Jia-sheng Zhou, Zhuo-yue Meng, Zi-qi Wu, Jia-cong Zhao, Hai-xiang Peng, Xin-yu Liang, Jun-jian Chen, Pei-pei Wang, Kai Deng
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice   Pages (1644-1659)
Luo-xing Xia, Ying-ying Xiao, Wen-jing Jiang, Xiang-yu Yang, Hua Tao, Safur Rehman M, ukhail, Jian-feng Qin, Qian-rong Pan, Yu-guang Zhu, Li-xin Zhao, Li-juan Huang, Zhan Li, Xi-yong Yu
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2   Pages (1660-1672)
Fan-le Zeng, Yuan Zhang, Zhong-hao Wang, Hui Zhang, Xue-teng Meng, Yi-qin Wu, Zhen-zhen Qian, Yu-hao Ding, Jun Li, Tao-tao Ma, Cheng Huang
Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis   Pages (1673-1685)
Ying Chen, Ming-fei Wu, Man-man Xie, Yang Lu, Chao Li, Shuai-shuai Xie, Wen-xian Ma, Ming-lu Ji, Rui Hou, Ze-hui Dong, Ruo-bing He, Meng-meng Zhang, Hao Lu, Li Gao, Jia-gen Wen, Juan Jin, Xiao-wu Dong, Jin-xin Che, Xiao-ming Meng
Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation   Pages (1686-1700)
Lin-lin Sun, Li-na Zhao, Jiao Sun, Hong-feng Yuan, Yu-fei Wang, Chun-yu Hou, Pan Lv, Hui-hui Zhang, Guang Yang, Ning-ning Zhang, Xiao-dong Zhang, Wei Lu
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma   Pages (1701-1714)
Qi-yi Zhang, Wen Ding, Jian-shan Mo, Shu-min Ou-yang, Zi-you Lin, Ke-ren Peng, Guo-pin Liu, Jin-jian Lu, Pei-bin Yue, Jin-ping Lei, Yan-dong Wang, Xiao-lei Zhang
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis   Pages (1715-1726)
Jian-qin Lai, Le-le Zhao, Chao Hong, Qiu-ming Zou, Jin-xuan Su, Si-jia Li, Xiao-feng Zhou, Zi-sheng Li, Bo Deng, Jie Cao, Qi Qi
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer   Pages (1727-1739)
Hui-fang Zong, Xi Li, Lei Han, Lei Wang, Jun-jun Liu, Ya-li Yue, Jie Chen, Yong Ke, Hua Jiang, Yue-qing Xie, Bao-hong Zhang, Jian-wei Zhu
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy   Pages (1740-1751)
Zhi-feng Zou, Lei Yang, Hui-jun Nie, Jing Gao, Shu-min Lei, Yi Lai, Fan Zhang, Ernst Wagner, Hai-jun Yu, Xiao-hua Chen, Zhi-ai Xu
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans   Pages (1752-1764)
Rui-jing Mu, Tian-lei Liu, Xiao-dong Liu, Li Liu