Vol 45, No 5 (May 2024): Acta Pharmacologica Sinica

Review Article

Structural and functional insights into the epigenetic regulator MRG15   Pages (879-889)
Nan Jiang, Yong-bo Li, Jia-yu Jin, Jie-yu Guo, Qiu-rong Ding, Dan Meng, Xiu-ling Zhi
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression   Pages (890-899)
Xiao-yu Ma, Man-man Chen, Ling-hua Meng

Article

Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models   Pages (900-913)
Xin-jie Guan, Zhi-qiang Deng, Jia Liu, Cheng-fu Su, Benjamin Chun-Kit Tong, Zhou Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Yu-xuan Kan, Ke-jia Lu, Carol Pui-Kei Chu, Rong-biao Pi, King-ho Cheung, Ashok Iyaswamy, Ju-xian Song, Min Li
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients   Pages (914-925)
Zhu-wei Miao, Nuo Wang, Wen-jun Hu, Si-li Zheng, Dong-sheng Wang, Fu-qiang Chang, Zhi Wang, Jia-sheng Tian, Xiao-hui Dong, Tao Wu, Chao-yu Miao
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes   Pages (926-944)
Jian Lu, An-xu He, Zhuo-ying Jin, Meng Zhang, Zhong-xin Li, Fan Zhou, Lin Ma, Hong-ming Jin, Jia-ying Wang, Xu Shen
Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats   Pages (945-958)
Ruo-song Chen, Jing Liu, Yu-jun Wang, Kuan Ning, Jing-gen Liu, Zhi-qiang Liu
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching   Pages (959-974)
Shi-chun Shen, Jie Xu, Cheng Cheng, Xin-jian Xiang, Bao-yu Hong, Meng Zhang, Chen Gong, Li-kun Ma
Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice   Pages (975-987)
Xiao Li, Zhen-chuan Lei, Chun Yin Lo, Tsz Yau Jan, Chi Wai Lau, Xiao-qiang Yao
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways   Pages (988-1001)
Yan-ni Zhao, Zhou-di Liu, Tao Yan, Ting-xin Xu, Tian-yang Jin, Yong-sheng Jiang, Wei Zuo, Kwang Youl Lee, Li-jiang Huang, Yi Wang
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis   Pages (1002-1018)
Ting-lv Fu, Guo-rui Li, Dong-hang Li, Ru-yuan He, Bo-hao Liu, Rui Xiong, Chen-zhen Xu, Zi-long Lu, Cong-kuan Song, Hong-liang Qiu, Wen-jie Wang, Shi-shi Zou, Ke Yi, Ning Li, Qing Geng
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice   Pages (1019-1031)
Fu-wen Zuo, Zhi-yong Liu, Ming-wei Wang, Jun-yao Du, Peng-zhong Ding, Hao-ran Zhang, Wei Tang, Yu Sun, Xiao-jie Wang, Yan Zhang, Yu-sheng Xie, Ji-chao Wu, Min Liu, Zi-ying Wang, Fan Yi
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis   Pages (1032-1043)
Yun-yang Qiao, Jia-ling Ji, Wei-ling Hou, Gao-ting Qu, Shan-wen Li, Xing-yue Li, Ran Jin, Yin-fang Li, Hui-min Shi, Ai-qing Zhang
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1   Pages (1044-1059)
Han Zhang, Fei Xie, Xiao-ya Yuan, Xin-tong Dai, Yun-feng Tian, Ming-ming Sun, Si-qi Yu, Jia-you Cai, Bin Sun, Wei-cheng Zhang, Chang-liang Shan
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer   Pages (1060-1076) Open
Ling-bing Li, Ling-xiao Yang, Lei Liu, Fan-rong Liu, Alex H. Li, Yi-lin Zhu, Hao Wen, Xia Xue, Zhong-xian Tian, Hong Sun, Pei-chao Li, Xiao-gang Zhao
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation   Pages (1077-1092)
Chen Cheng, Chao Ren, Mu-zi Li, Yi-hui Liu, Ren-qi Yao, Yang Yu, Xuan Yu, Jian-li Wang, Li-xue Wang, Yu-chun Leng, Hui Zhang, Fei-fei Du, Ning Dong, Feng-qing Wang, Yao Wu, Fang Xu, Xiao-mei Zhu, Gui-ping Zhang, Kai Dong, Si Liu, Xiao-qing Yao, Chuan Li, Yong-ming Yao

Correction

Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells   Pages (1093-1094)
Yue-hong Chen, Hao Lv, Ning Shen, Xiao-min Wang, Shuai Tang, Bing Xiong, Jian Ding, Mei-yu Geng, Min Huang