Vol 44, No 8 (August 2023): Acta Pharmacologica Sinica

Review Article

Regulated cell death pathways in cardiomyopathy   Pages (1521–1535)
Shu-yuan Sheng, Jia-min Li, Xin-yang Hu, Yibin Wang
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer   Pages (1536–1548) Open
Ting Wang, Yi Qin, Zeng Ye, De-sheng Jing, Gui-xiong Fan, Meng-qi Liu, Qi-feng Zhuo, Shun-rong Ji, Xue-min Chen, Xian-jun Yu, Xiao-wu Xu, Zheng Li

Article

RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B- dependent mechanism   Pages (1549–1563) Open
Hua-ping Du, Yi Guo, Yong-ming Zhu, De-fei Gao, Bo Lin, Yuan Liu, Yuan Xu, Ali Said, Taous Khan, Li-jun Liu, Jian-jun Zhu, Yong Ni, Hui-ling Zhang
Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers   Pages (1564–1575) Open
Ting-ting Tang, Ming-xia Bi, Mei-ning Diao, Xiao-yi Zhang, Ling Chen, Xue Xiao, Qian Jiao, Xi Chen, Chun-ling Yan, Xi-xun Du, Hong Jiang
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity   Pages (1576–1588)
Qiao Deng, Shao-qi Zhang, Ping-fen Yang, Wan-ting Dong, Fang Wang, Li-hong Long, Jian-guo Chen
Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy   Pages (1589–1599) Open
Gui-mei Yang, Fu-yun Tian, Yan-wen Shen, Chuan-yan Yang, Hui Yuan, Ping Li, Zhao-bing Gao
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission   Pages (1600–1611)
Yu Wang, Xiao-yun Qiu, Jia-ying Liu, Bei Tan, Fei Wang, Min-juan Sun, Xu-hong Jiang, Xu-ming Ji, Ceng-lin Xu, Yi Wang, Zhong Chen
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition   Pages (1612–1624)
Kai-li Hao, Qiao-cheng Zhai, Yue Gu, Yue-qiu Chen, Ya-ning Wang, Rui Liu, Shi-ping Yan, Ying Wang, Yu-fang Shi, Wei Lei, Zhen-ya Shen, Ying Xu, Shi-jun Hu
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs   Pages (1625–1636)
Xiao-kang Zhao, Meng-meng Zhu, Sheng-nan Wang, Ting-ting Zhang, Xiao-ning Wei, Cheng-yi Wang, Juan Zheng, Wen-ya Zhu, Mei-xiu Jiang, Suo-wen Xu, Xiao-xiao Yang, Ya-jun Duan, Bu-chun Zhang, Ji-hong Han, Qing R. Miao, Hao Hu, Yuan-li Chen
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β   Pages (1637–1648)
Shao-ru Chen, Zheng-qing Li, Jun Xu, Mo-yu Ding, Ya-ming Shan, Yung-chi Cheng, Gao-xiao Zhang, Ye-wei Sun, Yu-qiang Wang, Ying Wang
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis   Pages (1649–1664)
Wen-ji Yang, Fang-hui Han, Yi-pei Gu, Hui Qu, Jia Liu, Jian-hua Shen, Ying Leng
GPR84 regulates pulmonary inflammation by modulating neutrophil functions   Pages (1665–1675) Open
Si-wei Wang, Qing Zhang, Dan Lu, You-chen Fang, Xiao-ci Yan, Jing Chen, Zhi-kan Xia, Qian-ting Yuan, Lin-hai Chen, Yang-ming Zhang, Fa-jun Nan, Xin Xie
Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1α pathway   Pages (1676–1686)
Meng-yao Sun, Hui-jing Ye, Chen Zheng, Zi-jie Jin, Yan Yuan, Hong-bo Weng
Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases   Pages (1687–1700)
Hao-yu Wang, Xi Lin, Guan-gen Huang, Rong Zhou, Shu-yue Lei, Jing Ren, Kai-rong Zhang, Chun-lan Feng, Yan-wei Wu, Wei Tang
Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics   Pages (1701–1711)
Wen-si Zhao, Kai-feng Chen, Man Liu, Xing-long Jia, Yu-qi Huang, Bing-bing Hao, Hao Hu, Xiao-yan Shen, Qiang Yu, Min-jia Tan
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription   Pages (1712–1724)
Yu-fei Wang, Jin-yan Feng, Li-na Zhao, Man Zhao, Xian-fu Wei, Yu Geng, Hong-feng Yuan, Chun-yu Hou, Hui-hui Zhang, Guo-wen Wang, Guang Yang, Xiao-dong Zhang