Vol 44, No 6 (June 2023) - Acta Pharmacologica Sinica

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain Pages (1109–1121)

Guang-ying Li, Qiu-zi Wu, Tian-jia Song, Xue-chu Zhen, Xiang Yu

Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment Pages (1122–1134)

Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-tian Li, Zhi-jian Xu, Wei-liang Zhu, Nai-xia Zhang, Yang Ye, Lin-yin Feng

Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway Pages (1135–1148)

Hong-yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-jun Lu, Hai-gang Ren, Guang-hui Wang

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling Pages (1149–1160)

Hao Wu, Lu-xun Tang, Xue-mei Wang, Liang-peng Li, Xiao-kang Chen, Yan-ji He, De-zhong Yang, Yu Shi, Jia-ling Shou, Zong-shu Zhang, Liang Wang, Bing-jun Lu, Songzhu Michael An, Chun-yu Zeng, Wei Eric Wang

SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis Pages (1161–1174)

Jing-xuan Han, Lai-liu Luo, Yi-cheng Wang, Makoto Miyagishi, Vivi Kasim, Shou-rong Wu

MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway Pages (1175–1190) Open

Lin Yang, Wen-wen Shen, Wei Shao, Qing Zhao, Gao-zong Pang, Yi Yang, Xiao-fang Tao, Wei-ping Zhang, Qiong Mei, Yu-xian Shen

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells Pages (1191–1205)

Zi-bo Li, Lin Jiang, Jia-dong Ni, Yuan-hang Xu, Fang Liu, Wen-ming Liu, Shao-gui Wang, Zhong-qiu Liu, Cai-yan Wang

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy Pages (1206–1216)

Ji-chao Wu, Xiao-jie Wang, Jing-han Zhu, Xue-ying Huang, Min Liu, Zhe Qiao, Yan Zhang, Yu Sun, Zi-ying Wang, Peng Zhan, Tao Zhang, Hui-li Hu, Hong Liu, Wei Tang, Fan Yi

Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis Pages (1217–1226)

Si-yu Tian, Shu-ming Chen, Yong-yi Feng, Jia-ling He, Yong Li

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 Pages (1227–1237)

Li-hua Zhao, Qing-ning Yuan, An-tao Dai, Xin-heng He, Chuan-wei Chen, Chao Zhang, You-wei Xu, Yan Zhou, Ming-wei Wang, De-hua Yang, H. Eric Xu

Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases Pages (1238–1251)

Wan-di Feng, Yao Wang, Tong Luo, Xin Jia, Cui-qin Cheng, Hao-jia Wang, Mei-qi Zhang, Qi-qi Li, Xue-jiao Wang, Yi-ying Li, Jin-yong Wang, Guang-rui Huang, Ting Wang, An-long Xu

Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice Pages (1252–1261)

Hao-wen Xu, Wei-feng Li, Shan-shan Hong, Jing-jing Shao, Jia-hao Chen, Nipon Chattipakorn, Di Wu, Wu Luo, Guang Liang

Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway Pages (1262–1276)

Qi-qi Song, Li-ping Lin, Ya-li Chen, Jia-cheng Qian, Ke Wei, Jian-wei Su, Jian-hua Ding, Ming Lu, Yang Liu, Ren-xiang Tan, Gang Hu

IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma Pages (1277–1289) Open

Hada Buhe, Ji-xin Ma, Fang-zhou Ye, Chen-yun Song, Xin-yu Chen, Yang Liu, Huang Lin, Xu Han, Li-xiang Ma, Hexige Saiyin

AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage Pages (1290–1303)

Jin-peng Pei, Yue Wang, Lan-ping Ma, Xin Wang, Liang Liu, Yu Zhang, Rui Jin, Zhi-qiang Ren, Yan Deng, Jing-kang Shen, Tao Meng, Ker Yu

Vol 44, No 6 (June 2023): Acta Pharmacologica Sinica

Article

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain Pages (1109–1121)

Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment Pages (1122–1134)

Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway Pages (1135–1148)

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling Pages (1149–1160)

SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis Pages (1161–1174)

MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway Pages (1175–1190) Open

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells Pages (1191–1205)

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy Pages (1206–1216)

Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis Pages (1217–1226)

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 Pages (1227–1237)

Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases Pages (1238–1251)

Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice Pages (1252–1261)

Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway Pages (1262–1276)

IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma Pages (1277–1289) Open

AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage Pages (1290–1303)

Correction

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα Pages (1304)

Table of Contents

Cover Image

Vol 44, No 6 (June 2023): Acta Pharmacologica Sinica

Article

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain Pages (1109–1121)

Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment Pages (1122–1134)

Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway Pages (1135–1148)

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling Pages (1149–1160)

SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis Pages (1161–1174)

MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway Pages (1175–1190) Open

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells Pages (1191–1205)

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy Pages (1206–1216)

Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis Pages (1217–1226)

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 Pages (1227–1237)

Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases Pages (1238–1251)

Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice Pages (1252–1261)

Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway Pages (1262–1276)

IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma Pages (1277–1289) Open

AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage Pages (1290–1303)

Correction

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα Pages (1304)

Table of Contents

Cover Image

MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway Pages (1175–1190) Open