Vol 44, No 2 (February 2023): Acta Pharmacologica Sinica

Review Article

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels   Pages (259–267)
Young-Woo Nam, Myles Downey, Mohammad Asikur Rahman, Meng Cui, Miao Zhang
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin   Pages (268–287)
Lei Qin, Nian Liu, Chao-le-meng Bao, Da-zhi Yang, Gui-xing Ma, Wei-hong Yi, Guo-zhi Xiao, Hui-ling Cao
Immune-based combination therapy to convert immunologically cold tumors into hot tumors: an update and new insights   Pages (288–307)
Jiao-jiao Ni, Zi-zhen Zhang, Ming-jie Ge, Jing-yu Chen, Wei Zhuo

Article

Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway   Pages (308–320)
Dai-gang Yang, Yong-yao Gao, Ze-qun Yin, Xue-rui Wang, Xian-she Meng, Ting-feng Zou, Ya-jun Duan, Yuan-li Chen, Chen-zhong Liao, Zhou-ling Xie, Xiao-dong Fan, Lu Sun, Ji-hong Han, Xiao-xiao Yang
Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation   Pages (321–331)
Jian-rong Huang, Ming-hua Zhang, Ying-jie Chen, Yu-ling Sun, Zhi-min Gao, Zhuo-jia Li, Gui-ping Zhang, Yuan Qin, Xiao-yan Dai, Xi-yong Yu, Xiao-qian Wu
Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy   Pages (332–344)
Lei Wang, Xue-qing Tang, Yang Shi, Hui-min Li, Zi-yu Meng, Hui Chen, Xiao-han Li, Yong-chao Chen, Heng Liu, Yang Hong, Heng-hui Xu, Ling Liu, Limin Zhao, Wei-na Han, Xin Liu, Yong Zhang
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes   Pages (345–355)
Chun-ling Huang, Yu-na Huang, Lei Yao, Jun-ping Li, Zeng-hui Zhang, Zhao-qi Huang, Si-xu Chen, Yu-ling Zhang, Jing-feng Wang, Yang-xin Chen, Zhao-yu Liu
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function   Pages (356–366)
Xiang-hui Zhou, Zhi-peng Cheng, Meng Lu, Wen-yi Lin, Li-li Luo, Zhang-yin Ming, Yu Hu
Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis   Pages (367–380)
Bai-cheng Kuang, Zhi-heng Wang, Shuai-heng Hou, Ji Zhang, Meng-qin Wang, Jia-si Zhang, Kai-lun Sun, Hai-qiang Ni, Nian-qiao Gong
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis   Pages (381–392)
Tian-tian Wang, Ling-ling Wu, Jie Wu, Li-sheng Zhang, Wan-jun Shen, Ying-hua Zhao, Jiao-na Liu, Bo Fu, Xu Wang, Qing-gang Li, Xue-yuan Bai, Li-qiang Wang, Xiang-mei Chen
Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease   Pages (393–405)
Yan-ni Wang, Zhi-hao Zhang, Hong-jiao Liu, Zhi-yuan Guo, Liang Zou, Ya-mei Zhang, Ying-yong Zhao
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia   Pages (406–420)
Xiao-wei Li, Jian-hua Ran, Hong Zhou, Jin-zhao He, Zhi-wei Qiu, Shu-yuan Wang, Meng-na Wu, Shuai Zhu, Yong-pan An, Ang Ma, Min Li, Ya-zhu Quan, Nan-nan Li, Chao-qun Ren, Bao-xue Yang
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists   Pages (421–433)
Sanaz Darbalaei, Ru-lue Chang, Qing-tong Zhou, Yan Chen, An-tao Dai, Ming-wei Wang, De-hua Yang
14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling   Pages (434–445)
Jia-li Chen, Zhe-ling Feng, Fei Zhou, Ruo-han Lou, Cheng Peng, Yang Ye, Li-gen Lin
A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk   Pages (446–453)
Hao Zhang, Jie-mei Gu, Ai-jun Chao, Qun Cheng, Dong-hui Teng, Jin-ming Yu, Bing-wu Wang, Ya-nan Huo, Li Mao, Qiu Zhang, Hong Yang, Shi-gui Yan, Ke-qin Zhang, Xue-ling Zhao, Hua Lin, Yu Pei, Zhong Yuan, Ru-chun Dai, Liang He, Li Chen, Yong-feng Su, Zhong-liang Deng, Li You, Bo Ban, Mei Zhu, You-liang Cao, Yi-kun Zhu, Zhi-jun Li, Zhi Zhang, Cheng-qing Yi, Yi-bing Lu, Guang Wang, Cui-cui Han, Zhen-jiang Wang, Xian-xing Li, Zhen-lin Zhang
PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis   Pages (454–464)
Xiao-feng Li, Shu-qin Yin, Hao Li, Ying-li Yang, Xin Chen, Biao Song, Sha Wu, Yuan-yuan Wu, Hua Wang, Jun Li
An integrated PK/PD model investigating the impact of tumor size and systemic safety on animal survival in SW1990 pancreatic cancer xenograft   Pages (465–474)
Qing-yu Yao, Jun Zhou, Ye Yao, Jun-sheng Xue, Yu-chen Guo, Wei-zhe Jian, Ren-wei Zhang, Xiao-yan Qiu, Tian-yan Zhou
Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain   Pages (475–485)
Jing-yi Zhou, Rui-rui Yang, Jie Chang, Jia Song, Zi-sheng Fan, Ying-hui Zhang, Cheng-hao Lu, Hua-liang Jiang, Ming-yue Zheng, Su-lin Zhang

Correction

Author Correction: Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle   Pages (486–487)
Li-wen Ren, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Yi-hui Yang, Sha Li, Sen Zhang, Wei-qi Fu, Bin Xiao, Jin-hua Wang, Guan-hua Du
Publisher Correction: Publisher correction for multiple articles   Pages (488)
Editorial Office