Vol 43, No 11 (November 2022) - Acta Pharmacologica Sinica

Review Article

Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy Pages (2749–2758)

Jun-hao Li, Lu-jia Huang, Hui-ling Zhou, Yi-ming Shan, Fang-min Chen, Vesa-Pekka Lehto, Wu-jun Xu, Li-qiang Luo, Hai-jun Yu

Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy Pages (2759–2776)

Anubhab Mukherjee, Bharti Bisht, Suman Dutta, Manash K. Paul

The diverse role of the raphe 5-HTergic systems in epilepsy Pages (2777–2788)

He-ming Cheng, Chen-shu Gao, Qiu-wen Lou, Zhong Chen, Yi Wang

Novel insights into NOD-like receptors in renal diseases Pages (2789–2806)

Juan Jin, Tao-jie Zhou, Gui-ling Ren, Liang Cai, Xiao-ming Meng

Article

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia Pages (2807–2816)

Li-shi Fan, You-chao Chen, Ru-jia Liao, Yan-yan Zhao, Xiang-nan Zhang, Zhong Chen, Lei Jiang, Wei-wei Hu

Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window Pages (2817–2827)

Ling Pan, Wei-dong Tang, Ke Wang, Qi-feng Fang, Meng-ru Liu, Zhan-xun Wu, Yi Wang, Sun-liang Cui, Gang Hu, Ting-jun Hou, Wei-wei Hu, Zhong Chen, Xiang-nan Zhang

Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice Pages (2828–2840)

Ye-ru Chen, Shu-xia Zhang, Man Fang, Piao Zhang, You-fa Zhou, Xin Yu, Xiang-nan Zhang, Gang Chen

NGF monoclonal antibody DS002 alleviates chemotherapy-induced peripheral neuropathy in rats Pages (2841–2847)

Zhi-juan Liang, Jie Tan, Lei Tang, Zuo-bin Xie, Gan-jun Chen, Guo-jian Liu, Lin Yuan, Kai-xin Wang, Hua-ping Ding, Hong Qiu, Qi Wang, Gui-feng Wang, Yi-li Chen, Chun-he Wang

Increased intracellular Cl⁻ concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases Pages (2848–2861)

Hui Han, Chang Liu, Mei Li, Jin Wang, Yao-sheng Liu, Yi Zhou, Zi-cheng Li, Rui Hu, Zhi-hong Li, Ruo-mei Wang, Yong-yuan Guan, Bin Zhang, Guan-lei Wang

Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis Pages (2862–2872)

Tian-yu Li, Wei Su, Liang-liang Li, Xiao-guang Zhao, Na Yang, Jia-xin Gai, Xin Lv, Jing Zhang, Meng-qin Huang, Qing Zhang, Wei-hang Ji, Xiao-ying Song, Yu-hong Zhou, Xue-lian Li, Hong-li Shan, Hai-hai Liang

Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy Pages (2873–2884)

Xiao-yun Ji, Dong Zheng, Rui Ni, Jin-xi Wang, Jian-qiang Shao, Zer Vue, Antentor Hinton Jr., Long-Sheng Song, Guo-Chang Fan, Subrata Chakrabarti, Zhao-liang Su, Tian-qing Peng

The transplantation of rapamycin-treated senescent human mesenchymal stem cells with enhanced proangiogenic activity promotes neovascularization and ischemic limb salvage in mice Pages (2885–2894)

Yu-lin Cao, Wen-lan Chen, Qian Lei, Fei Gao, Wen-xiang Ren, Li Chen, Hong-xiang Wang, Ting Chen, Qiu-bai Li, Zhi-chao Chen

Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells Pages (2895–2904)

Li-jun Liang, Di Wang, Hong Yu, Jun Wang, Hui Zhang, Bei-bei Sun, Fu-ying Yang, Zheng Wang, Da-wei Xie, Rui-e Feng, Kai-feng Xu, Gui-zhen Wang, Guang-biao Zhou

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin Pages (2905–2916)

Nan Sheng, Yun-qiu Wang, Cun-fu Wang, Meng-qi Jia, Huan-min Niu, Qi-qi Lu, Ya-nan Wang, Dan Feng, Xiao-xue Zheng, Hui-qing Yuan

Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells Pages (2917–2928)

Hao Shen, Han Yu, Qian-yu Li, Ya-ting Wei, Jing Fu, Hui Dong, Dan Cao, Lin-na Guo, Lei Chen, Yuan Yang, Ying Xu, Meng-chao Wu, Hong-yang Wang, Yao Chen

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice Pages (2929–2945)

Gang Cao, Hua Miao, Yan-ni Wang, Dan-qian Chen, Xia-qing Wu, Lin Chen, Yan Guo, Liang Zou, Nosratola D. Vaziri, Ping Li, Ying-yong Zhao

Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9 Pages (2946–2955)

Lu Liang, Wen-yan Xu, Ao Shen, Hui-yu Cen, Zhi-jun Chen, Lin Tan, Ling-min Zhang, Yu Zhang, Ji-jun Fu, Ai-ping Qin, Xue-ping Lei, Song-pei Li, Yu-yan Qin, Jiong-hua Huang, Xi-yong Yu

c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression Pages (2956–2966)

Wen-die Wang, Yue Shang, Chen Wang, Jun Ni, Ai-min Wang, Gao-jie Li, Ling Su, Shu-zhen Chen

Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis Pages (2967–2976)

Juan Yang, Rong-rong Miao, Ya-nan Li, Ting Pan, Shu-hua Wu, Xian-jun Qu, Shu-xiang Cui

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (2977–2992)

Xiang-jin Zheng, Wen-lin Chen, Jie Yi, Wan Li, Jin-yi Liu, Wei-qi Fu, Li-wen Ren, Sha Li, Bin-bin Ge, Yi-hui Yang, Yi-zhi Zhang, Hong Yang, Guan-hua Du, Yu Wang, Jin-hua Wang

Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin Pages (2993–3001)

Na Hui Kim, Minji Kwon, Jiwoo Jung, Hyo Byeong Chae, Jiwoo Lee, Yeo-Jun Yoon, In Seok Moon, Ho K. Lee, Wan Namkung, Konstantina M. Stankovic, Se A. Lee, Jong Dae Lee, Sin-Aye Park

Brief Communication

A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network Pages (3002–3010)

Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S. Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R. Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang

Correction

Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (3011–3012)

Xiang-jin Zheng, Wen-lin Chen, Jie Yi, Wan Li, Jin-yi Liu, Wei-qi Fu, Li-wen Ren, Sha Li, Bin-bin Ge, Yi-hui Yang, Yi-zhi Zhang, Hong Yang, Guan-hua Du, Yu Wang, Jin-hua Wang

Vol 43, No 11 (November 2022): Acta Pharmacologica Sinica

Review Article

Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy Pages (2749–2758)

Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy Pages (2759–2776)

The diverse role of the raphe 5-HTergic systems in epilepsy Pages (2777–2788)

Novel insights into NOD-like receptors in renal diseases Pages (2789–2806)

Article

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia Pages (2807–2816)

Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window Pages (2817–2827)

Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice Pages (2828–2840)

NGF monoclonal antibody DS002 alleviates chemotherapy-induced peripheral neuropathy in rats Pages (2841–2847)

Increased intracellular Cl⁻ concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases Pages (2848–2861)

Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis Pages (2862–2872)

Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy Pages (2873–2884)

The transplantation of rapamycin-treated senescent human mesenchymal stem cells with enhanced proangiogenic activity promotes neovascularization and ischemic limb salvage in mice Pages (2885–2894)

Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells Pages (2895–2904)

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin Pages (2905–2916)

Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells Pages (2917–2928)

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice Pages (2929–2945)

Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9 Pages (2946–2955)

c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression Pages (2956–2966)

Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis Pages (2967–2976)

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (2977–2992)

Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin Pages (2993–3001)

Brief Communication

A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network Pages (3002–3010)

Correction

Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (3011–3012)

Table of Contents

Cover Image

Vol 43, No 11 (November 2022): Acta Pharmacologica Sinica

Review Article

Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy Pages (2749–2758)

Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy Pages (2759–2776)

The diverse role of the raphe 5-HTergic systems in epilepsy Pages (2777–2788)

Novel insights into NOD-like receptors in renal diseases Pages (2789–2806)

Article

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia Pages (2807–2816)

Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window Pages (2817–2827)

Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice Pages (2828–2840)

NGF monoclonal antibody DS002 alleviates chemotherapy-induced peripheral neuropathy in rats Pages (2841–2847)

Increased intracellular Cl− concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases Pages (2848–2861)

Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis Pages (2862–2872)

Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy Pages (2873–2884)

The transplantation of rapamycin-treated senescent human mesenchymal stem cells with enhanced proangiogenic activity promotes neovascularization and ischemic limb salvage in mice Pages (2885–2894)

Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells Pages (2895–2904)

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin Pages (2905–2916)

Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells Pages (2917–2928)

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice Pages (2929–2945)

Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9 Pages (2946–2955)

c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression Pages (2956–2966)

Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis Pages (2967–2976)

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (2977–2992)

Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin Pages (2993–3001)

Brief Communication

A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network Pages (3002–3010)

Correction

Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis Pages (3011–3012)

Table of Contents

Cover Image

Increased intracellular Cl⁻ concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases Pages (2848–2861)