Vol 43, No 1 (January 2022): Acta Pharmacologica Sinica

Review Article

Regulatory T cells in ischemic stroke   Pages (1-9)
Hong-yun Wang, Jun-rui Ye, Li-yuan Cui, Shi-feng Chu, Nai-hong Chen
Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease   Pages (10-14)
Ya-lin Wang, Xiu Zhou, Dong-li Li, Ji-ming Ye

Article

Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice   Pages (15–25)
Yu-shan Wan, Yi You, Qian-yun Ding, Yi-xin Xu, Han Chen, Rong-rong Wang, Yu-wen Huang, Zhong Chen, Wei-wei Hu, Lei Jiang
Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats   Pages (26–38)
Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis   Pages (39–49)
Zhi-yun Zhu, Yan-dong Liu, Yan Gong, Wei Jin, Elena Topchiy, Subat Turdi, Yue-feng Gao, Bruce Culver, Shu-yi Wang, Wei Ge, Wen-liang Zha, Jun Ren, Zhao-hui Pei, Xing Qin
Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy   Pages (50–63)
Jie Huang, Yang Liu, Jia-xin Chen, Xin-ya Lu, Wen-jia Zhu, Le Qin, Zi-xuan Xun, Qiu-yi Zheng, Er-min Li, Ning Sun, Chen Xu, Hai-yan Chen
Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China   Pages (64–75)
Xue-qing Liu, Shan Xue, Jia-bo Xu, Heng Ge, Qing Mao, Xin-hui Xu, Han-dong Jiang
Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2   Pages (76–85)
Ya-li Zhang, Wen-xin Zhang, Jue-qian Yan, Ye-lin Tang, Wen-jing Jia, Zheng-wei Xu, Ming-jiang Xu, Nipon Chattipakorn, Yi Wang, Jian-peng Feng, Zhi-guo Liu, Guang Liang
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease   Pages (86–95)
Fan Yin, Pei-qing Zheng, Liu-qi Zhao, Yan-zhe Wang, Nai-jun Miao, Zhuan-li Zhou, Qian Cheng, Pan-pan Chen, Hong-yan Xie, Jing-yao Li, Jia-yun Ni, Li Zhou, Wei Zhang, Xiao-xia Wang, Jun Liu, Li-min Lu
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease   Pages (96–110) Open
Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu, Wei Zhu, Xian Wang, Yong-gui Wu, Xiao-ming Meng, Xiang-ming Qi
Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice   Pages (111–120) Open
Stefan Wörner, Bernhard N. Bohnert, Matthias Wörn, Mengyun Xiao, Andrea Janessa, Andreas L. Birkenfeld, Kerstin Amann, Christoph Daniel, Ferruh Artunc
CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia   Pages (121–132)
Ze-an Zhao, Yu Jiang, Yan-yu Chen, Ting Wu, Qun-sheng Lan, Yong-mei Li, Lu Li, Yang Yang, Cui-ting Lin, Ying Cao, Ping-zheng Zhou, Jia-yin Guo, Yuan-xin Tian, Jian-xin Pang
N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice   Pages (133-145)
Dai-fei Shen, He Cheng, Bo-zhi Cai, Wen-feng Cai, Bin Wang, Qing Zhu, Yue-bin Wu, Man Liu, Run-ji Chen, Fen-fei Gao, Yan-mei Zhang, Yong-dong Niu, Gang-gang Shi
PXR mediates mifepristone-induced hepatomegaly in mice   Pages (146–156)
Xin-peng Yao, Ting-ying Jiao, Yi-ming Jiang, Shi-cheng Fan, Ying-yuan Zhao, Xiao Yang, Yue Gao, Fei Li, Yan-ying Zhou, Pan-pan Chen, Min Huang, Hui-chang Bi
DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation   Pages (157–166)
Wei Nie, Min-juan Hu, Qin Zhang, Jun Lu, Fang-fei Qian, Le-le Zhang, Fang Hu, Chang-hui Li, Shu-hui Cao, Jing-wen Li, Yue Wang, Xue-yan Zhang, Mi-die Xu, Bao-hui Han
PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway   Pages (167–176)
Mei-sa Wang, Qiu-shuang Han, Zhi-rong Jia, Chuan-sheng Chen, Chen Qiao, Qian-qian Liu, Ya-meng Zhang, Kai-wei Wang, Jie Wang, Kang Xiao, Xuan-sheng Ding
Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis   Pages (177–193) Open
Li-wen Shen, Xiu-xing Jiang, Zhi-qiang Li, Jie Li, Mei Wang, Guan-fei Jia, Xin Ding, Ling Lei, Qi-hai Gong, Ning Gao
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle   Pages (194–208)
Li-wen Ren, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Yi-hui Yang, Sha Li, Sen Zhang, Wei-qi Fu, Bin Xiao, Jin-hua Wang, Guan-hua Du
SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma   Pages (209–219)
Xi Zhang, Yu-ting Duan, Yi Wang, Xing-dong Zhao, Yi-ming Sun, Dong-ze Lin, Yi Chen, Yu-xiang Wang, Zu-wen Zhou, Yan-xin Liu, Li-hua Jiang, Mei-yu Geng, Jian Ding, Ling-hua Meng
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies   Pages (220–228)
Kai-long Jiang, Le-xian Tong, Tao Wang, Han-lin Wang, Xiao-bei Hu, Gao-ya Xu, Ting-ting Jin, Wei-juan Kan, Lei Xu, Jia-nan Li, Kai-xiang Zhang, Ning Song, Jie-yu Liu, Meng-meng Zhang, Wen-biao Wu, Yu-qi Xiang, An-hui Gao, Yong-zhou Hu, Yu-bo Zhou, Tao Liu, Jian-min Yang, Jia Li
Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays   Pages (229–239)
Jin-ping Pang, Chao Shen, Wen-fang Zhou, Yun-xia Wang, Lu-hu Shan, Xin Chai, Ying Shao, Xue-ping Hu, Feng Zhu, Dan-yan Zhu, Li Xiao, Lei Xu, Xiao-hong Xu, Dan Li, Ting-jun Hou
Establishment of an in vitro safety assessment model for lipid- lowering drugs using same-origin human pluripotent stem cell- derived cardiomyocytes and endothelial cells   Pages (240-250)
Xuan Ni, Zhuang-zhuang Yang, Ling-qun Ye, Xing-long Han, Dan-dan Zhao, Feng-yue Ding, Nan Ding, Hong-chun Wu, Miao Yu, Guang-yin Xu, Zhen-ao Zhao, Wei Lei, Shi-jun Hu