Vol 42, No 12 (December 2021): Acta Pharmacologica Sinica

Review Article

Natural products: potential treatments for cisplatin-induced nephrotoxicity   Pages (1951–1969)
Chun-yan Fang, Da-yong Lou, Li-qin Zhou, Jin-cheng Wang, Bo Yang, Qiao-jun He, Jia-jia Wang, Qin-jie Weng
Response prediction biomarkers and drug combinations of PARP inhibitors in prostate cancer   Pages (1970–1980)
Yi-xin Chen, Li-ming Tan, Jian-ping Gong, Ma-sha Huang, Ji-ye Yin, Wei Zhang, Hong-hao Zhou, Zhao-qian Liu
Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer   Pages (1981–1990)
Momeneh Ghanaat, Nasser Hashemi Goradel, Arash Arashkia, Nasim Ebrahimi, Sajjad Ghorghanlu, Ziba Veisi Malekshahi, Esmail Fattahi, Babak Negahdari, Hami Kaboosi

Article

Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson’s disease models   Pages (1991–2003)
Wen-li Dong, Jia-hong Zhong, Yun-qing Chen, Jin-feng Xie, Yun-yun Qin, Jiang-ping Xu, Ning-bo Cai, Meng-fan Li, Lu Liu, Hai-tao Wang
Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2   Pages (2004–2015)
Lei-lei Ma, Fei-juan Kong, Yuan-ji Ma, Jun-jie Guo, Shi-jun Wang, Zheng Dong, Ai-jun Sun, Yun-zeng Zou, Jun-bo Ge
Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation   Pages (2016–2032)
Si-lin Lv, Zi-fan Zeng, Wen-qiang Gan, Wei-qi Wang, Tie-gang Li, Yu-fang Hou, Zheng Yan, Ri-xin Zhang, Min Yang
Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics   Pages (2033–2045)
Li-tao Wang, Peng-cheng He, An-qi Li, Kai-xiang Cao, Jing-wei Yan, Shuai Guo, Lei Jiang, Lin Yao, Xiao-yan Dai, Du Feng, Yi-ming Xu, Ning Tan
MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding protein   Pages (2046–2057)
Yin Cai, Yu Zhang, Hui Chen, Xing-hui Sun, Peng Zhang, Lu Zhang, Meng-yang Liao, Fang Zhang, Zheng-yuan Xia, Ricky Ying-keung Man, Mark W. Feinberg, Susan Wai-Sum Leung
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells   Pages (2058–2068)
Xuan Zhang, Ying Dong, Wan-chen Li, Bi-xi Tang, Jia Li, Yi Zang
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway   Pages (2069–2081)
Ya-xian Wu, Ying-ying Wang, Zhi-qi Gao, Dan Chen, Gang Liu, Bin-bin Wan, Feng-juan Jiang, Ming-xia Wei, Jing Zuo, Jun Zhu, Yong-quan Chen, Feng Qian, Qing-feng Pang
BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis   Pages (2082–2093)
Guan-chao Mao, Chu-chu Gong, Zhen Wang, Ming-xue Sun, Zhi-peng Pei, Wen-qi Meng, Jin-feng Cen, Xiao-wen He, Ying Lu, Qing-qiang Xu, Kai Xiao
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats   Pages (2094–2105)
Yong-zhen Liu, Heng-lei Lu, Xin-ming Qi, Guo-zhen Xing, Xin Wang, Pan Yu, Lu Liu, Fang-fang Yang, Xiao-lan Ding, Ze-an Zhang, Zhong-ping Deng, Li-kun Gong, Jin Ren
FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling   Pages (2106–2119)
Zuo-lin Li, Bin Wang, Lin-li Lv, Tao-tao Tang, Yi Wen, Jing-yuan Cao, Xiao-xiao Zhu, Song-tao Feng, Steven D. Crowley, Bi-cheng Liu
Y06014 is a selective BET inhibitor for the treatment of prostate cancer   Pages (2120–2131)
Tian-bang Wu, Qiu-ping Xiang, Chao Wang, Chun Wu, Cheng Zhang, Mao-feng Zhang, Zhao-xuan Liu, Yan Zhang, Lin-jiu Xiao, Yong Xu
Cystine supplementation rebalances the redox homeostasis of microenvironment in non-small cell lung cancer cells and reverses their resistance to docetaxel   Pages (2132–2143)
Si-jia Li, Bei Cao, Zhen-yao Lu, Run-bin Sun, Su-han Guo, Yuan Xie, Ji-ye Aa, Guang-ji Wang
Mitochondrial proteome of mouse oocytes and cisplatin- induced shifts in protein profile   Pages (2144–2154) Open
Na Zhang, An-di Sun, Si-man Sun, Rui Yang, Yan-yan Shi, Qi-long Wang, Xin-yu Li, Ji-hong Ma, Wei Yue, Bing-teng Xie, Jie Qiao, Mo Li
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule   Pages (2155–2172)
Xiao-fang Lan, Olajide E. Olaleye, Jun-lan Lu, Wei Yang, Fei-fei Du, Jun-ling Yang, Chen Cheng, Yan-hong Shi, Feng-qing Wang, Xue-shan Zeng, Nan-nan Tian, Pei-wei Liao, Xuan Yu, Fang Xu, Ying-fei Li, Hong-tao Wang, Nai-xia Zhang, Wei-wei Jia, Chuan Li

Brief Communication

Estrogen-dependent KCa1.1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats   Pages (2173–2180)
Lu-qi Wang, Zhao Qian, Hai-lan Ma, Meng Zhou, Hu-die Li, Chang-peng Cui, Da-li Luo, Xue-lian Li, Bai-yan Li