Vol 42, No 10 (October 2021): Acta Pharmacologica Sinica

Review Article

Structure, regulation, and biological functions of TIGAR and its role in diseases   Pages (1547-1555)
Jie Tang, Lei Chen, Zheng-hong Qin, Rui Sheng

Article

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex   Pages (1556-1566)
Xiao-jing Li, Yuan-yuan Zhang, Yu-hua Fu, Hao Zhang, He-xuan Li, Quan-fu Li, Hai-ling Li, Ren-ke Tan, Chen-xiao Jiang, Wei Jiang, Zeng-xia Li, Cheng Luo, Bo-xun Lu, Yong-jun Dang
Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography   Pages (1567-1574) Open
Rui Li, Hong Wang, Fei Ma, Guang-lin Cui, Li-yuan Peng, Chen-ze Li, He-song Zeng, Ali J. Marian, Dao-wen Wang
6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway   Pages (1575-1586)
Shu-qing Ma, Zhen Guo, Fang-yuan Liu, Shahzad-Gul Hasan, Dan Yang, Nan Tang, Peng An, Ming-yu Wang, Hai-ming Wu, Zheng Yang, Di Fan, Qi-zhu Tang
Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress   Pages (1587-1597)
Qian Wu, Jia-hui Tian, Yong-xiang He, Yong-yin Huang, Yu-qing Huang, Gui-ping Zhang, Jian-dong Luo, Qin Xue, Xi-yong Yu, Ying-hua Liu
A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction   Pages (1598-1609)
Chak Kwong Cheng, Jiang-Yun Luo, Chi Wai Lau, William Chi-shing Cho, Chi Fai Ng, Ronald Ching Wan Ma, Xiao Yu Tian, Yu Huang
Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis   Pages (1610-1619)
Sai-nan Chen, Ying Tan, Xiao-chan Xiao, Qian Li, Qi Wu, You-you Peng, Jun Ren, Mao-long Dong
Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice   Pages (1620-1629)
Ling-ling Jia, Ming Zhang, He Liu, Jia Sun, Li-long Pan
Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis   Pages (1630-1641)
Jian-jian Ji, Qin-mei Sun, Deng-yun Nie, Qian Wang, Han Zhang, Fen-fen Qin, Qi-sheng Wang, Sheng-feng Lu, Guo-ming Pang, Zhi-gang Lu
Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection   Pages (1642-1652)
Zhao-wei Gao, Ling Li, Yuan-yuan Huang, Cai-qi Zhao, Shuang-jia Xue, Jie Chen, Zhong-zhou Yang, Jin-fu Xu, Xiao Su
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis   Pages (1653-1664)
Yu-ting Liu, Hui-hua Ding, Ze-min Lin, Que Wang, Li Chen, Shuang-shuang Liu, Xiao-qian Yang, Feng-hua Zhu, Yue-teng Huang, Shi-qi Cao, Fang-ming Yang, Zi-lan Song, Jian Ding, Mei-yu Geng, Hua Xie, Ao Zhang, Shi-jun He, Jian-ping Zuo
BAFF, involved in B cell activation through the NF-κB pathway, is related to disease activity and bone destruction in rheumatoid arthritis   Pages (1665-1675)
Ling-ling Zhang, Hui Xiao, Feng Zhang, Yu-jing Wu, Jin-ling Shu, Ying Li, Yu Tai, Sheng-qian Xu, Jian-hua Xu, Wei Wei
ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway   Pages (1676-1689)
Liang-yun Li, Jun-fa Yang, Fan Rong, Zhi-pan Luo, Shuang Hu, Hui Fang, Ying Wu, Rui Yao, Wei-hao Kong, Xiao-wen Feng, Bang-jie Chen, Jun Li, Tao Xu
ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron   Pages (1690-1702) Open
Shan Lu, Xuan-zhong Wang, Chuan He, Lei Wang, Shi-peng Liang, Chong-cheng Wang, Chen Li, Tian-fei Luo, Chun-sheng Feng, Zhen-chuan Wang, Guang-fan Chi, Peng-fei Ge
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor   Pages (1703-1713)
Abudumijiti Abulizi, Ling Hu, Ang Ma, Fang-yu Shao, Hui-ze Zhu, Si-mei Lin, Guang-ying Shao, Yue Xu, Jian-hua Ran, Jing Li, Hong Zhou, Dong-mei Lin, Lian-fu Wang, Min Li, Bao-xue Yang
Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel   Pages (1714-1722)
Yun-qiu Miao, Ming-shu Chen, Xin Zhou, Lin-miao Guo, Jing-jing Zhu, Rui Wang, Xin-xin Zhang, Yong Gan

Correction

Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ   Pages (1723-1724)
Ya-kun Meng, Chun-yu Li, Rui-yu Li, Lan-zhi He, He-rong Cui, Ping Yin, Cong-en Zhang, Peng-yan Li, Xiu-xiu Sang, Ya Wang, Ming Niu, Ya-ming Zhang, Yu-ming Guo, Rong Sun, Jia-bo Wang, Zhao-fang Bai, Xiao-he Xiao