Vol 42, No 9 (September 2021): Acta Pharmacologica Sinica

Correspondence

Beyond iron deposition: making sense of the latest evidence on ferroptosis in Parkinson’s disease   Pages (1379-1381)
Hai-ying Zhu, Qiao-jun He, Bo Yang, Ji Cao

Review Article

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease   Pages (1382-1389)
Feng Zhang, Ru-jia Zhong, Cheng Cheng, Song Li, Wei-dong Le
Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target   Pages (1390-1400)
Xin Zhang, Can Hu, Hai-ming Wu, Zhen-guo Ma, Qi-zhu Tang

Article

Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer’s disease rat model   Pages (1401-1408)
Lei Zhu, Xiao-jie Hou, Xiao-hang Che, Ting-shuo Zhou, Xiao-qi Liu, Chun-fu Wu, Jing-yu Yang
Ginsenoside Rg1 exerts neuroprotective effects in 3- nitropronpionic acid-induced mouse model of Huntington’s disease via suppressing MAPKs and NF-κB pathways in the striatum   Pages (1409-1421)
Xiong Yang, Shi-feng Chu, Zhen-zhen Wang, Fang-fang Li, Yu-he Yuan, Nai-hong Chen
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction   Pages (1422-1436)
Yan-qing Ding, Yu-hong Zhang, Jing Lu, Bai Li, Wen-jing Yu, Zhong-bao Yue, Yue-huai Hu, Pan-xia Wang, Jing-yan Li, Si-dong Cai, Jian-tao Ye, Pei-qing Liu
The vascular endothelial growth factor trap aflibercept induces vascular dysfunction and hypertension via attenuation of eNOS/NO signaling in mice   Pages (1437-1448)
Zhi-chao Dong, Ming-ming Wu, Yun-long Zhang, Qiu-shi Wang, Chen Liang, Xiao Yan, Lei-xin Zou, Chen Chen, Xiao Han, Bo Zhang, Zhi-ren Zhang
3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity   Pages (1449-1460)
Jangho Lee, Ji-Hye Song, Min-Yu Chung, Jin-Hyuk Lee, Tae-Gyu Nam, Jae Ho Park, Jin-Taek Hwang, Hyo-Kyoung Choi
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway   Pages (1461-1471)
Jian-yi Dong, Kai-jun Xia, Wei Liang, Lu-lu Liu, Fang Yang, Xue-sheng Fang, Yong-jian Xiong, Liang Wang, Zi-juan Zhou, Chang-yi Li, Wei-dong Zhang, Jing-yu Wang, Da-peng Chen
Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma   Pages (1472-1485)
Chan-juan Zhang, Neng Zhu, Jia Long, Hong-tao Wu, Yu-xiang Wang, Bi-yuan Liu, Duan-fang Liao, Li Qin
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition   Pages (1486-1497) Open
Qiu-di Deng, Xue-ping Lei, Yi-hang Zhong, Min-shan Chen, Yuan-yu Ke, Zhan Li, Jing Chen, Li-juan Huang, Yu Zhang, Lu Liang, Zhong-xiao Lin, Qing Liu, Song-pei Li, Xi-yong Yu
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo   Pages (1498-1506)
Meng-di Dai, Yue-liang Wang, Jun Fan, Yang Dai, Yin-chun Ji, Yi-ming Sun, Xia Peng, Lan-lan Li, Yu-ming Wang, Wen-hu Duan, Jian Ding, Jing Ai
4-Methoxydalbergione is a potent inhibitor of human astroglioma U87 cells in vitro and in vivo   Pages (1507-1515)
Ran Li, Chang-qiong Xu, Jian-xin Shen, Qiu-yun Ren, Di-ling Chen, Mian-jie Lin, Rong-ni Huang, Chun-hui Li, Ru-ting Zhong, Zhi-hua Luo, Xiao-yu Ji, Jie Wu
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy   Pages (1516-1523)
Zhi-di He, Meng Zhang, Yong-hui Wang, Yang He, Hai-rui Wang, Bin-fan Chen, Bin Tu, Si-qi Zhu, Yong-zhuo Huang
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists   Pages (1524-1534)
Ming-cheng Yu, Feng Yang, Xiao-yu Ding, Nan-nan Sun, Zheng-yuan Jiang, Ya-fei Huang, Yu-rong Yan, Chen Zhu, Qiong Xie, Zhi-feng Chen, Si-qi Guo, Hua-liang Jiang, Kai-xian Chen, Cheng Luo, Xiao-min Luo, Shi-jie Chen, Yong-hui Wang
Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans   Pages (1535-1546)
Yuan-dong Zheng, Hua Zhang, Yan Zhan, Yi-cong Bian, Sheng Ma, Hai-xian Gan, Xiao-juan Lai, Yong-qiang Liu, Yan-chun Gong, Xue-fang Liu, Hong-bin Sun, Yong-guo Li, Da-fang Zhong, Li-yan Miao, Xing-xing Diao