Vol 39, No 10 (October 2018): Acta Pharmacologica Sinica

Article

Astragaloside IV ameliorates neuroinflammationinduced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis   Pages (1559–1570)
Mei-ting SONG, Jie RUAN, Ru-yi ZHANG, Jie DENG, Zhan-qiang MA, Shi-ping MA
Pharmacological and functional comparisons of α6/ α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line   Pages (1571–1581)
De-jie CHEN, Fen-fei GAO, Xiao-kuang MA, Gang-gang SHI, Yuan-bing HUANG, Quang-xi SU, Sterling SUD-WEEKS, Ming GAO, Turner DHARSHAUN, Jason Brek EATON, Yong-chang CHANG, J Michael MCINTOSH, Ronald J LUKAS, Paul WHITEAKER, Scott C STEFFENSEN, Jie WU
Prolonged DADLE exposure epigenetically promotes Bcl-2 expression and elicits neuroprotection in primary rat cortical neurons via the PI3K/Akt/NF-κB pathway   Pages (1582–1589)
Min ZHU, Ming LIU, Qi-lin GUO, Cui-qing ZHU, Jing-chun GUO
Manipulation-free cultures of human iPSC-derived cardiomyocytes offer a novel screening method for cardiotoxicity   Pages (1590–1603)
Sheeja RAJASINGH, Dona Greta ISAI, Saheli SAMANTA, Zhi-gang ZHOU, Buddhadeb DAWN, William H KINSEY, Andras CZIROK, Johnson RAJASINGH
Activation of CaMKIIδA promotes Ca2+ leak from the sarcoplasmic reticulum in cardiomyocytes of chronic heart failure rats   Pages (1604–1612)
Le GUI, Xin GUO, Zhe ZHANG, Hui XU, Ya-wei JI, Ren-jun WANG, Jiang-hua ZHU, Qing-hui CHEN
Anti-inflammatory activities of hepatocyte growth factor in post-ischemic heart failure   Pages (1613–1621)
Shu-ling RONG, Xiao-lin WANG, Yi-cheng WANG, Huan WU, Xue-dong ZHOU, Ze-kun WANG, Yu-chuan WANG, Cun-shui XUE, Bao LI, Dong-lai GAO
Novel substituted pyrazolone derivatives as AMPactivated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice   Pages (1622–1632)
Mei ZHANG, Zhi-fu XIE, Run-tao ZHANG, Da-kai CHEN, Min GU, Shi-chao CUI, Yang-ming ZHANG, Xin-wen ZHANG, Yan-yan YU, Jia LI, Fa-jun NAN, Jing-ya LI
Artemisinin analogue SM934 ameliorates DSSinduced mouse ulcerative colitis via suppressing neutrophils and macrophages   Pages (1633–1644)
Yu-xi YAN, Mei-juan SHAO, Qing QI, Yan-sheng XU, Xiao-qian YANG, Feng-hua ZHU, Shi-jun HE, Pei-lan HE, Chun-lan FENG, Yan-wei WU, Heng LI, Wei TANG, Jian-ping ZUO
Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway   Pages (1645–1660)
Zhong WANG, Qiang CHEN, Bin LI, Jia-ming XIE, Xiao-dong YANG, Kui ZHAO, Yong WU, Zhen-yu YE, Zheng-rong CHEN, Zheng-hong QIN, Chun-gen XING
Nrf2 mediates the resistance of human A549 and HepG2 cancer cells to boningmycin, a new antitumor antibiotic, in vitro through regulation of glutathione levels   Pages (1661–1669)
Hui-xian ZHANG, Yang CHEN, Rong XU, Qi-yang HE
Combined treatment with apatinib and docetaxel in A549 xenograft mice and its cellular pharmacokinetic basis   Pages (1670–1680)
Si-qi FENG, Guang-ji WANG, Jing-wei ZHANG, Yuan XIE, Run-bin SUN, Fei FEI, Jing-qiu HUANG, Ying WANG, Ji-ye AA, Fang ZHOU
Delivery of mitochondriotropic doxorubicin derivatives using self-assembling hyaluronic acid nanocarriers in doxorubicin-resistant breast cancer   Pages (1681–1692)
Hui-na LIU, Ning-ning GUO, Wang-wei GUO, Ming-yi HUANG-FU, Mohammad Reza VAKILI, Jie-jian CHEN, Wen-hong XU, Qi-chun WEI, Min HAN, Afsaneh LAVASANIFAR, Jian-qing GAO

Review Article

Oncogene-induced senescence: a double edged sword in cancer   Pages (1553–1558)
Xue-ling LIU, Jian DING, Ling-hua MENG