Vol 37, No 10 (October 2016): Acta Pharmacologica Sinica

Review

Histone lysine methyltransferases as anti-cancer targets for drug discovery   Pages (1273-1280)
Qing LIU, Ming-wei WANG

Original Article

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance   Pages (1281-1297)
Xiao-dan GUO, Guang-long SUN, Ting-ting ZHOU, Xin XU, Zhi-yuan ZHU, Vatcharin RUKACHAISIRIKUL, Li-hong HU, Xu SHEN
Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway   Pages (1298-1306)
Zheng LI, Qian-qian MA, Yan YAN, Feng-dan XU, Xiao-ying ZHANG, Wei-qin ZHOU, Zhi-chun FENG
A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins   Pages (1307-1314) Open
Peng WU, Ming-xing LU, Xiao-tian CUI, He-qing YANG, Shen-liang YU, Jian-bin ZHU, Xiao-li SUN, Boxun LU
Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity   Pages (1315-1324)
Zhao-xiang REN, Ya-fei ZHAO, Ting CAO, Xue-chu ZHEN
Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GABAergic transmission onto the neurons at both pre- and postsynaptic sites   Pages (1325-1336)
Yu SUN, Shi-yu JIANG, Jian NI, Yan-jia LUO, Chang-rui CHEN, Zong-yuan HONG, Yuchio YANAGAWA, Wei-min QU, Lu WANG, Zhi-li HUANG
Betulin attenuates atherosclerosis in apoE−/− mice by up-regulating ABCA1 and ABCG1   Pages (1337-1348)
Yu-zhou GUI, Hong YAN, Fei GAO, Cong XI, Hui-hui LI, Yi-ping WANG
Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro   Pages (1349-1358)
Xian-wei WANG, Fen-xi ZHANG, Fen YANG, Zu-feng DING, Nidhi AGARWAL, Zhi-kun GUO, Jawahar L MEHTA
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition   Pages (1359-1369)
Shan-yao MA, Meng-meng NING, Qing-an ZOU, Ying FENG, Yang-liang YE, Jian-hua SHEN, Ying LENG
Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae   Pages (1370-1380)
Shi-ying LUO, Jing-feng CHEN, Zhi-guo ZHONG, Xiao-hua LV, Ya-jun YANG, Jing-jing ZHANG, Liao CUI
Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition   Pages (1381-1390)
Yi-ming MA, Yan-min PENG, Qiong-hua ZHU, An-hui GAO, Bo CHAO, Qiao-jun HE, Jia LI, You-hong HU, Yu-bo ZHOU