Vol 33, No 4 (April 2012): Acta Pharmacologica Sinica

Research Highlight

A new antihypertensive drug ameliorate insulin resistance   Pages (429–430)
Yan-xia Liu

Original Article

Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation   Pages (431–437)
Feng Sun, Jian-dong Sun, Ning Han, Chuang-jun Li, Yu-he Yuan, Dong-ming Zhang, Nai-hong Chen
Ginsenoside Rb1 selectively inhibits the activity of L-type voltage-gated calcium channels in cultured rat hippocampal neurons   Pages (438–444)
Zhi-ying Lin, Li-min Chen, Jing Zhang, Xiao-dong Pan, Yuan-gui Zhu, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen
Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils   Pages (445–451)
Juan Qu, Yun-na Gan, Ke-liang Xie, Wen-bo Liu, Ya-fei Wang, Ren-yi Hei, Wen-juan Mi, Jian-hua Qiu
Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus   Pages (452–458)
Min Zhang, Wei-yi Fang, Fang Yuan, Xin-kai Qu, Hua Liu, Ying-jia Xu, Hui Chen, Yong-fu Yu, Yan Shen, Zhi-chun Zheng
Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats   Pages (459–469)
Monika Ivanová, Ima Dovinová, Ľudmila Okruhlicová, Narcisa Tribulová, Petra Šimončíková, Monika Barte-ková, Jana Vlkovičová, Miroslav Barančík
CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines   Pages (470–478)
Guo-lin Zhang, Feng Yu, De-zai Dai, Yu-si Cheng, Can Zhang, Yin Dai
Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway   Pages (479–489)
Bo Ma, Qi Zhang, Di Wu, Yong-lu Wang, Ying-ying Hu, Yan-ping Cheng, Zhen-dong Yang, Ya-ya Zheng, Han-Jie Ying
Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency   Pages (490–495)
Hao Zhang, Qi-ren Huang, Jie-mei Gu, Wei-wei Hu, Yu-juan Liu, Yun-qiu Hu, Zhen-lin Zhang
Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucose-treated endothelial cells   Pages (496–502)
Qiong Xu, Bin Zhang, Xiao-mu Li, Xin Gao
Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice   Pages (503–512)
Jun Yan, Fang Hua, Han-zhi Liu, Hong-zheng Yang, Zhuo-wei Hu
Lentivirus-mediated RNA silencing of c-Met markedly suppresses peritoneal dissemination of gastric cancer in vitro and in vivo   Pages (513–522)
Xiao-lei Wang, Xi-mei Chen, Jian-ping Fang, Chang-qin Yang
Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model   Pages (523–530)
Li-hua Lai, Qi-hong Fu, Yang Liu, Kai Jiang, Qing-ming Guo, Qing-yun Chen, Bin Yan, Qing-qing Wang, Jian-gen Shen
Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways   Pages (531–541)
Lei Lü, Dong Tang, Liang Wang, Lu-qi Huang, Guo-song Jiang, Xing-yuan Xiao, Fu-qing Zeng
Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro   Pages (542–550)
Yin Tong, Yan-yan Liu, Liang-shun You, Wen-bin Qian
Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway   Pages (551–557)
Yan-jun Zhang, Cheng-rong Lu, Yan Cao, Yuan Luo, Rong-feng Bao, Shu Yan, Mei Xue, Feng Zhu, Zhe Wang, Lian-ning Duan
Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways   Pages (558–567)
Daniel Pens Gelain, Matheus Augusto de Bittencourt Pasquali, Fernanda Freitas Caregnato, Mauro Antonio Alves Castro, José Claudio Fonseca Moreira
Covalent protein binding and tissue distribution of houttuynin in rats after intravenous administration of sodium houttuyfonate   Pages (568–576)
Zhi-peng Deng, Da-fang Zhong, Jian Meng, Xiao-yan Chen