Vol 45, No 11 (November 2024): Acta Pharmacologica Sinica

Review Article

The regulation and function of Nrf2 signaling in ferroptosis- activated cancer therapy   Pages (2229-2240)
Xin Jiang, Min Yu, Wei-kai Wang, Li-yuan Zhu, Xian Wang, Hong-chuan Jin, Li-feng Feng

Article

Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability   Pages (2241-2252)
Xiao-ling Zhang, Wei-hong Du, Shu-xia Qian, Xu-dong Lu, Xin Yu, Hai-lun Fang, Jia-li Dong, Min Song, Yan-yun Sun, Xiao-qiang Wu, Yu-fei Shen, Ya-nan Hao, Min-hui Shen, Bei-qun Zhou, Yan-ping Wang, Cong-ying Xu, Xin-chun Jin
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity   Pages (2253-2266)
Jian-chi Ma, Xiao-hang Che, Xiao-na Zhu, Ao-xin Ren, Yue Hu, Cheng-li Yang, Zhong-tian Xu, Yu-ting Li, Chun-fu Wu, Jing-yu Yang
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies   Pages (2267-2276)
Jing-fen Su, Yue Xiao, Lin-yu Wei, Hui-yang Lei, Fei Sun, Wei-xia Wang, Shi-hong Li, Xiao-chuan Wang, Jie Zheng, Jian-zhi Wang
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice   Pages (2277-2289)
Meng-yun Xu, Jing-jing Xu, Li-jing Kang, Zheng-hong Liu, Mei-ming Su, Wen-qi Zhao, Zhi-hua Wang, Lu Sun, Jian-bo Xiao, Paul C. Evans, Xiao-yu Tian, Li Wang, Yu Huang, Xin-miao Liang, Jian-ping Weng, Suo-wen Xu
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals   Pages (2290-2299)
Zi-yang Chen, Si-jia Ji, Chen-wen Huang, Wan-zhi Tu, Xin-yue Ren, Ren Guo, Xin Xie
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner   Pages (2300-2312)
Bian-lei Yang, Yao-ying Long, Qian Lei, Fei Gao, Wen-xiang Ren, Yu-lin Cao, Di Wu, Liu-yue Xu, Jiao Qu, He Li, Ya-li Yu, An-yuan Zhang, Shan Wang, Hong-xiang Wang, Zhi-chao Chen, Qiu-bai Li
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis   Pages (2313-2327)
Ying-quan Wen, Zi-yuan Zou, Guan-guan Zhao, Meng-jiao Zhang, Yong-xin Zhang, Gai-hong Wang, Jing-jing Shi, Yuan-yang Wang, Ye-yu Song, Hui-xia Wang, Ru-ye Chen, Dong-xuan Zheng, Xiao-qun Duan, Ya-meng Liu, Frank J. Gonzalez, Jian-gao Fan, Cen Xie
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1   Pages (2328–2338)
Hui-ling Xiang, Qian Yuan, Jie-yu Zeng, Zi-yu Xu, Hui-zi Zhang, Jing Huang, An-ni Song, Jing Xiong, Chun Zhang
Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease   Pages (2339-2353)
Peng-jie Yang, Xiang-yu Zhao, Yao-hui Kou, Jia Liu, Xiang-yi Ren, Yuan-yuan Zhang, Zhi-dong Wang, Zhen Ge, Wei-xin Yuan, Chen Qiu, Bing Tan, Qin Liu, Yan-na Shi, Yuan-qing Jiang, Cong Qiu, Li-he Guo, Jin-ying Li, Xiao-jun Huang, Lu-yang Yu
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages   Pages (2354-2365)
De-chong Zheng, Jia-qin Hu, Chu-tian Mai, Li Huang, Hua Zhou, Li-li Yu, Ying Xie
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase   Pages (2366-2379)
You-tian Hu, Zhi-wei Liu, Tong-hui Zhang, Yu-e Ma, Lei He, Jie Zhang, Yue-yang Zhou, Antonio Vidal-Puig, De-jing Pan, Fang Wu
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity   Pages (2380-2393)
Yin-yan Li, Guo-dong Liang, Zhi-xuan Chen, Ke Zhang, Jin-long Liang, Lin-rui Jiang, Si-zu Yang, Feng Jiang, Shu-wen Liu, Jie Yang
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation   Pages (2394-2404)
Xiang He, Jiang-ling Lu, Wen-feng Liao, Yi-ru Long, Xing Zhang, Qian Zhu, Heng-lei Lu, Geng-yan Hao, Kan Ding, Jian-hua Sun, Li-kun Gong, Yi-fu Yang
HBXIP induces PARP1 via WTAP-mediated m6A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma   Pages (2405-2419)
Xue-li Fu, Shi-man Guo, Jia-qi Ma, Fang-yuan Ma, Xue Wang, Yan-xin Tang, Ye Li, Wei-ying Zhang, Li-hong Ye
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma   Pages (2420 -2431)
Xiao Fang, Wen-ying Yu, Chun-miao Zhu, Nan Zhao, Wei Zhao, Ting-ting Xie, Li-jie Wei, Xi-ran Sun, Juan Xie, Ya Zhao
Structural insights into somatostatin receptor 5 bound with cyclic peptides   Pages (2432-2440)
Ying-ge Li, Xian-yu Meng, Xiru Yang, Sheng-long Ling, Pan Shi, Chang-lin Tian, Fan Yang
Structural basis of tolvaptan binding to the vasopressin V2 receptor   Pages (2441-2449)
Hong-li Liu, Hai-yang Zhong, Yi-xiao Zhang, Hua-rui Xue, Zheng-shuo Zhang, Ke-quan Fu, Xu-dong Cao, Xiao-chun Xiong, Dong Guo

Author Correction

Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH/PSAT1/serine metabolic pathway   Pages (2450-2451)
Sha Li, Hong Yang, Wan Li, Jin-yi Liu, Li-wen Ren, Yi-hui Yang, Bin-bin Ge, Yi-zhi Zhang, Wei-qi Fu, Xiang-jin Zheng, Guan-hua Du, Jin-hua Wang
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice   Pages (2452-2452)
Xin-huang Lv, Xiao-xia Cong, Jin-liang Nan, Xing-mei Lu, Qian-li Zhu, Jian Shen, Bei-bei Wang, Zhi-ting Wang, Ri-yong Zhou, Wei-an Chen, Lan Su, Xiao Chen, Zheng-zheng Li, Yi-nuo Lin

Correction

Author Correction: A new tau dephosphorylation-targeting chimera for the treatment of tauopathies   Pages (2453 -2454)
Jing-fen Su, Yue Xiao, Lin-yu Wei, Hui-yang Lei, Fei Sun, Wei-xia Wang, Shi-hong Li, Xiao-chuan Wang, Jie Zheng, Jian-zhi Wang