Vol 46, No 3 (March 2025): Acta Pharmacologica Sinica

Perspective

How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease   Pages (515-524)
Brian E. Harvey

Review Article

Modulation of autophagy by melatonin and its receptors: implications in brain disorders   Pages (525-538)
Chen-ze Zhu, Gui-zhi Li, Hai-feng Lyu, Yang-yang Lu, Yue Li, Xiang-nan Zhang
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets   Pages (539-553)
Meng Sun, Zhen-ru Chen, Hui-juan Ding, Jing Feng
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms   Pages (554-564) Open
Eileen Chen, Lei Xi
AI-driven antibody design with generative diffusion models: current insights and future directions   Pages (565-574)
Xin-heng He, Jun-rui Li, James Xu, Hong Shan, Shi-yi Shen, Si-han Gao, H. Eric Xu

Article

Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism   Pages (575-591)
Nai-jun Yuan, Wen-jun Zhu, Qing-yu Ma, Min-yi Huang, Rou-rou Huo, Kai-jie She, Jun-ping Pan, Ji-gang Wang, Jia-xu Chen
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop   Pages (592-605)
Shu-ting Yu, Zhi-yong Sun, Na Li, Zhe-zhe Qu, Chang-hao Wang, Tian-tian Ju, Ying-qi Liu, Zhong-ting Mei, Kui-wu Liu, Mei-xi Lu, Min Huang, Ying Li, Shun-kang Dou, Jian-hao Jiang, Yao-zhi Zhang, Chuan-hao Huang, Xiao-chen Pang, Ying-qiong Jia, Xian-hui Dong, Fan Wu, Yi Zhang, Wan-hong Li, Bao-feng Yang, Wei-jie Du
Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload   Pages (606-617)
Le Pan, Chao Yin, Ke-jia Jin, Chen-xing Huang, Xiang Wang, Ying Wang, Suguro Rinkiko, Jian-guo Jia, Guo-ping Zhang, Yi-zhun Zhu, Yu-xiang Dai, Yun-zeng Zou, Hui Gong
A recombinant fragment antigen-binding (Fab) of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes: first evidence and the key implication of FcγRIIA receptor   Pages (618-631)
Anna De Bartolo, Naomi Romeo, Alessandro Marrone, Vittoria Rago, Maria Concetta Granieri, Maria Luigia Vommaro, Arianna Cupelli, Maria Carmela Cerra, Cesare Indiveri, Raffaele Ronca, Maria Cantile, Riccardo Sanna, Carmine Rocca, Tommaso Angelone
Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice   Pages (632-652)
Yu-wen Liu, Ru-yue Luo, An-qi Liu, Jia-wei Wang, Na-ping Hu, Wang-ting Li, Jian-kang Li, Jing-wen Wang, Jia-lin Duan
Sequential activation of ERα-AMPKα signaling by the flavonoid baicalin down-regulates viral HNF-dependent HBV replication   Pages (653-661) Open
Yi-jun Niu, Cheng-jie Xia, Xin Ai, Wei-ming Xu, Xiao-tong Lin, Ying-qi Zhu, Hai-yan Zhu, Xian Zeng, Zhong-lian Cao, Wei Zhou, Hai Huang, Xun-long Shi
Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway   Pages (662-671)
Ji Wang, Meng-yu Zhong, Yun-xia Liu, Jia-yu Yu, Yi-bin Wang, Xue-jiao Zhang, Hai-peng Sun
A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2   Pages (672-686)
Cheng-hong Hu, Yue Chen, Tian-yang Jin, Zhe Wang, Bo Jin, Jing Liao, Chun-yong Ding, Ao Zhang, Wei-yang Tang, Ling-xi Zhang, Lei-yu Xu, Fang-min Ning, Guang Liang, Xiao-hong Wei, Yi Wang
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice   Pages (687–701)
Wen-han Wu, Hao Zhi, Wen-ke Feng, Ling Jiang, Lu Yang, Li-qiang Qian, Rui-xi Zhao, Yong-mei Tan, Han-yu Yang, Xiao-dong Liu, Li Liu
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors   Pages (702-714)
Lin-hui Zhai, Xing-long Jia, Yu-lu Chen, Mu-yin Liu, Jing-dan Zhang, Shao-jie Ma, Xiu-jun Wang, Wen-hao Cheng, Jing-liang He, Jiao-jiao Zhou, Ling-yi Zuo, Mei-qi Zhang, Qing Yuan, Meng-han Xu, Jing Ji, Min-jia Tan, Bin Liu
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5   Pages (715-727)
Tian-tian Wang, Long-long Zhang, Fu-bing Li, Jie Zhang, Zhi-bi Zhang, Da-zhao Mi, Jian Sun, Hong-yan Zhang, Chun-yan Wang, Yi-hua Chen, Ce-shi Chen
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers   Pages (728-739) Open
Rui-xue Xia, Pei-chen Zou, Jun-ting Xie, Ya-bin Tang, Miao-miao Gong, Fu Fan, Ayinazhaer Aihemaiti, Yu-qing Liu, Ying Shen, Bin-bing S. Zhou, Liang Zhu, Hui-min Lei
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth   Pages (740-750)
Qing-yong Hu, Lei Li, Yu-huang Li, Hai-bo Zhang, Tao Deng, Yang Liu, Feng-tian Li, Zhi-xiong Xiao, Yang Cao
Longitudinal and time-to-event modeling for the survival of advanced pancreatic ductal adenocarcinoma patients   Pages (751-758)
Qing-yu Yao, Ping-yao Luo, Ling-xiao Xu, Rong Chen, Jun-sheng Xue, Ling Yong, Lin Shen, Jun Zhou, Tian-yan Zhou
Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE−/− mice via inhibiting macrophage foam-cell formation   Pages (759-776)
Rong-rong He, Chuan-rui Ma, Xin He, Yan-xi Dong, Hui Li, Zi-xuan Chu, Xi-he Yang, Jia-qi Wang, Tian-yan Zhou, Feng-qing Wang, Fei-fei Du, Ying Rao, Wen-xuan Yu, Xiu-mei Gao, Guan-wei Fan, Chen Cheng, Chuan Li
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice   Pages (777-793) Open
Yao-geng Wang, Chang-pei Gan, Joke Beukers-Korver, Hilde Rosing, Wen-long Li, Els Wagenaar, Maria C. Lebre, Ji-ying Song, Colin Pritchard, Rahmen Bin Ali, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel

Author Correction

Author Correction: CaIPF14030 negatively modulates intracellular ATP levels during the development of azole resistance in Candida albicans   Pages (794)
Xin-ming Jia, Ying Wang, Jun-dong Zhang, Hong-yue Tan, Yuan-ying Jiang, Jun Gu