Original Article

Inhibition of formalin-induced responses of spinal dorsal horn neurons by stimulation of lateral reticular nucleus in rats.

Guo-Zhen Zhao, Rong-Yuan Liu, Zhi-Qi Zhao

Abstract

The effects of stimulation of the lateral reticular nucleus (LRN) on responses of spinal dorsal horn neurons produced by formalin (5%, 50 microliters, sc) were investigated. In 12 out of 19 neurons tested, formalin induced 2 distinct phases of response. The first phase was initiated immediately after the injection of formalin and lasted for 3-8 min. The second phase started gradually 20-35 min after administration of formalin and lasted 30-65 min. Both phases of the response were inhibited by LRN stimulation.
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