Effects of [D-Ala2-O-benzyl-Ser5]-enkephalin on CAl field potentials in rat hippocampal slices
Abstract
[D-Ala2-O-benzyl-Ser5]-enkephalin (DABS) showed 2 effects upon the evoked potentials recorded in CA1 cell body layer: 1) production of naloxone-reversible additional population spike (PS). and 2) enhancement of the primary PS which was partially reversed by naloxone in most experiments. The differential antagonism of the two effects by naloxone suggested that they might be mediated by different opiate receptor subtypes. The mechanism of augmentation by DABS of the evoked potentials could be attributed to disinhibition as judged from the paired-pulse paradigm.
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