Study on antidotes of homoharringtonine

In 38 normal mice after ip homoharringtonine (HHT) 2 mg/(kg-d) x5 d with the observation period of 7 d. about 50% of mice died. HHT in combination with glycine or monoammonium glycyrrhizinate (MAG). batyl alcohol cepharanthine. astragalus polysaccharides (APS), polysaccharides of Acanthopanax senticosus (PAS), ginsenoside, chlorpromazine increased the mortality of mice. EDTA-Na and razoxane had no influence on the toxicity of HHT. HHT and sodium phenobarbital (SPB) injected simultaneously to mice also increased the mortality of mice. When SPB was administrated 3 d before HHT, the toxicity of HHT diminished. This regimen showed no marked influence on the antitumor activity of HHT at the dosage of l mg/kg.