Effects of m-nisoldipine and nisoldipine on hemodynamics in anesthetized dogs

m-nisoldipine (m-Nis), isobutyl methyl l, 4- dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3, 5-pyridine dicarboxylate, is a new calcium antagonistic compound, first developed in Department of Organic Chemistry. Hebei Medical College. The hemodynamic effects of iv m-Nis have been evaluated in anesthetized dogs in comparison with those of nisoldipine (Nis). The decrease in systolic blood pressure and heart rate by iv m-Nis 3 Vg/kg were less prominent than that by the same dose of Nis. While the diastolic pressure and index of MVO2 were reduced equally by both. m-Nis I and 3 Vg/kg iv increased the aortic blood flow, however. Nis in the same dose failed to do so. The fall of total peripheral resistance by iv m-Nis 1 Vg/kg and increase of cardiac index by iv m-Nis 1 and 3 Vg/kg were more significant than those by Nis in the same dose. The decrease of coronary and femoral arterial resistance by iv m-Nis 1 and 3 ug/kg were equal to that by Nis. and decrease of vertebral and renal arterial resistance by m-Nis were more remarkable than that by Nis.