Original Article

Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors

Yi-He Yao, Zhi-Qiang Chi

Abstract

Ohmefentanyl, a highly selective agonist for u opioid receptors, produced a naloxone-reversible inhibition of amphetamine-induced ipsilateral and apomorphine-induced contralateral rotation in rats with 6-hydroxy-dopamine-induced unilateral lesion of nigrostriatal neurons. Acute treatments of ohmefentanyl and morphine decreased dopamine receptor density and inhibited the enhanced binding of [3H]spiperone to rat striatal dopamine receptors induced by denervation. It is proposed that these two drugs probably have an indirect inhibitory effect on postsynaptic dopamine receptors in rat striatum.
Keywords:

Article Options

Download Citation

Cited times in Scopus