Experimental therapy of 7 antimalarials in mice infected with pyronaridine-resistant berghei
Abstract
Seven antimalarials were used in treating mice infected with plaswtodiuwt berghei or pyronaridine-resistant(RP)line of p. berghei.The result showed that RP line was cross-resistant to chloroquine, piperaquine, quinine and quinacrine but susceptible to pyrimethamine and sulfadoxine. The ED50 of pyrimethamine and sulfadoxine were 52.2 and 0.67 mg/kg/d x3, respectively. Artemisinine was effective to RP line at a higher dosage. and its ED50 was 1034 mg/kg/d x 3. pyrimethamine in combination with sulfadoxine resulted in a potentiating effect against pyronaridine-resistant line of p.berghei.
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