Pharmacokinetics of fluorocarbon blood substitute

The pharmacokinetics of fluorocarbon emulsions (FCE) was investigated in rats and monkeys. The blood levels of FCE after iv 15 g/kg in 4 monkeys decreased in 2 phases, the distributive phase and the eliminative phase, with half-lives of 3.8 h and 44 h, respectively. The pharmacokinctic parameters calculated according to the two-compartment open model were: a = 0.1846lh, (3 = 0.0106/h, K10 = 0.0470,K12 = 0.0920, K21 = 0.0612, V1 =0.4032 l/kg, V2 = 0.6102 1/kg, Vd = 1.2162 11 kg, A =136 mg/ml, B=50 mg/ml, clearance K10 V1 = 0. 0190 l/h. However, the blood FCE levels data after iv FCE 9 g/kg in rats adequately fitted to one-cornparment open model, t1/2 = 10 h. After iv FCE 9 g/kg in rats the highest FCE level was found in splcen, moderate in liver and lowest in kidneys, indicating an accumulation in the reticuloendothelial system. FCE disappeared completely from all organs in 2 mopths, which was in agreement with the results of pharmacokinetic analysis.