Comparative epileptogenic properties of cefazolin and benzylpenicillin after lntracaudate micro-lnjectlon in rats
Abstract
The epileptogenic properties of cefazolin given unilaterally into the caudate nucleus of rats were compared with those by equimolar doses of benzylpenicillin. Cefazolin produced a dose-dependent increase in locomotor activity, circling, stereotyped behavior and myoclonic jerks associated witb bigh voltage spikes and other bioelectric paroxysmal discharges. In comparison to benzylpenicijjin. cefazolin was more powerful on a molar basis and the epileptogenic disorders were longer-lasting.
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