Inhibitory effect of morphine on guinea pig ileum contrac-tion was modified by four monoamine blockers
Abstract
Guinea-pig ileum myenteric plexus longitudinal muscle preparations (GPIML) were madeca). Morphine HCI (0.1 ym) in hibited the electrically-induced contraction by 47%, which was completely reversed by naloxone. This effect of mor-phine was significantly augmented by a 5-HT blocking agent cinanserin (0.01 uM, +si%, P<0.01) and attenuated by an a-adrenergic blocking agent phentolamine (0.01 uM, - 28%, P
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