Original Article

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Min-fang Tao, Zeng Zhang, Yao-hua Ke, Jin-wei He, Wen-zhen Fu, Chang-qing Zhang, Zhen-lin Zhang
DOI: 10.1038/aps.2013.13

Abstract

Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively.
Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).
Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.
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