Effects of stereochemical aspects on drug interaction in pharmacokinetics.
Abstract
Recent literatures on enantiomer/enantiomer and enantiomer/coadministered drug
interactions in pharmacokinetics were reviewed. The clinical significance of
introducing the concept of stereoselectivity into pharmacokinetic interaction
study cannot be overestimated, such as avoiding interaction-based adverse
reactions, increasing therapeutic index, resolving the apparent anomaly in the
plasma concentration-effect relationship and providing starting point of
investigation into drug disposition, etc. Study in this respect should be
enhanced.
Keywords:
interactions in pharmacokinetics were reviewed. The clinical significance of
introducing the concept of stereoselectivity into pharmacokinetic interaction
study cannot be overestimated, such as avoiding interaction-based adverse
reactions, increasing therapeutic index, resolving the apparent anomaly in the
plasma concentration-effect relationship and providing starting point of
investigation into drug disposition, etc. Study in this respect should be
enhanced.