Effect of captopril on proliferation of aortic smooth muscle cells
Abstract
AIM: To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC).
METHODS:
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).
RESULTS: Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).
CONCLUSION: Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.
Keywords:
METHODS:
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).
RESULTS: Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).
CONCLUSION: Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.