Effects of total coumarins of Cnidium monnieri on bone density and biomechanics of glucocorticoids-induced osteoporosis in rats
Abstract
AIM: To evaluate the effects of total coumarins from dried fruits of Cnidium
monnieri (TCCM) on glucocorticoids (GC)-induced osteoporosis (OP) in rats.
METHODS: Single photon absorptiometric and biomechanical character measurements
of femurs were used.
RESULTS: The bone density (BD) indices in proximal, middle, and distal segments
in GC group were decreased by 12% (P < 0.05), 14% (P < 0.05), and 12% (P < 0.05),
respectively vs control group. The BD on proximal, middle, and distal segments in
GC-TCCM group were increased by 26% (P < 0.01), 34% (P < 0.01), and 31% (P <
0.01), respectively vs GC group. The biomechanical competence in femoral middle
segments in GC group tended to decrease vs control group. In GC-TCCM group, the
torsional strength, energy, maximal torsional angle, and rigidity were increased
by 15% (P < 0.05), 32% (P < 0.05), 14% (P > 0.05), and 13% (P > 0.05),
respectively vs the GC group.
CONCLUSION: TCCM not only prevented glucocorticoids-induced osteoporosis but also
increased the torsional strength of femurs in rats.
Keywords:
monnieri (TCCM) on glucocorticoids (GC)-induced osteoporosis (OP) in rats.
METHODS: Single photon absorptiometric and biomechanical character measurements
of femurs were used.
RESULTS: The bone density (BD) indices in proximal, middle, and distal segments
in GC group were decreased by 12% (P < 0.05), 14% (P < 0.05), and 12% (P < 0.05),
respectively vs control group. The BD on proximal, middle, and distal segments in
GC-TCCM group were increased by 26% (P < 0.01), 34% (P < 0.01), and 31% (P <
0.01), respectively vs GC group. The biomechanical competence in femoral middle
segments in GC group tended to decrease vs control group. In GC-TCCM group, the
torsional strength, energy, maximal torsional angle, and rigidity were increased
by 15% (P < 0.05), 32% (P < 0.05), 14% (P > 0.05), and 13% (P > 0.05),
respectively vs the GC group.
CONCLUSION: TCCM not only prevented glucocorticoids-induced osteoporosis but also
increased the torsional strength of femurs in rats.