Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats
Abstract
AIM: To study the actions of salvianolic acid A (SA-A) on liver injury and liver
fibrosis.
METHODS: The liver fibrotic rat was made by i.p. injection of CCl4. The model
rats were divided into 3 groups treated with SA-A, colchicine (Col), and Salvia
miltiorrhiza Bunge (SMB), respectively. Six wk later the rat liver pathology was
examined, type I and III collagen in the liver were examined by
immunohistochemistical method. Also hydroxyproline (Hyd) and malondialdehyde
(MDA) in the liver, alanine aminotransferase (AlaAT), aspartate aminotransferase
(AspAT), and albumin (Alb) levels in the serum were measured.
RESULTS: SA-A inhibited serum AlaAT and AspAT activities, decreased MDA and Hyd
contents, alleviated liver fibrogenesis, protected deposition of type I and III
collagen in liver matrix. The actions of SA-A on liver fibrosis were similar to
those of Col and SMB, action of SA-A decreasing MDA was better than that of Col.
CONCLUSION: SA-A has marked effects against liver injury and fibrosis, associated
with its anti-lipid peroxidation actions.
Keywords:
fibrosis.
METHODS: The liver fibrotic rat was made by i.p. injection of CCl4. The model
rats were divided into 3 groups treated with SA-A, colchicine (Col), and Salvia
miltiorrhiza Bunge (SMB), respectively. Six wk later the rat liver pathology was
examined, type I and III collagen in the liver were examined by
immunohistochemistical method. Also hydroxyproline (Hyd) and malondialdehyde
(MDA) in the liver, alanine aminotransferase (AlaAT), aspartate aminotransferase
(AspAT), and albumin (Alb) levels in the serum were measured.
RESULTS: SA-A inhibited serum AlaAT and AspAT activities, decreased MDA and Hyd
contents, alleviated liver fibrogenesis, protected deposition of type I and III
collagen in liver matrix. The actions of SA-A on liver fibrosis were similar to
those of Col and SMB, action of SA-A decreasing MDA was better than that of Col.
CONCLUSION: SA-A has marked effects against liver injury and fibrosis, associated
with its anti-lipid peroxidation actions.