Dextromethorphan metabolic phenotyping in a Chinese population
Abstract
AIM: To establish a phenotyping of dextromethorphan (DM) oxidation polymorphism
in a native Chinese population.
METHODS: The urine concentrations of DM and its metabolite dextrophan (DX) were
assayed by HPLC and metabolic ratios (MR) were calculated in 120 unrelated native
Chinese subjects after ingestion of DM 20 mg.
RESULTS: The incidence of poor metabolizers was 0.8% (one in 120 subjects). There
were distinct dimodal distributions which divided extensive metabolizers into 43
intermediate metabolizers and 76 very extensive metabolizers. The 0-8 h urinary
recoveries of DM and DX were 0.4% +/- s 0.5% and 26% +/- s 13%, respectively.
There was no difference in 0-8 h urinary recoveries between male and female
subjects.
CONCLUSION: DM metabolic phenotyping provides a new information for debrisoquine
4-hydroxylation (CYP2D6) polymorphism in native Chinese.
Keywords:
in a native Chinese population.
METHODS: The urine concentrations of DM and its metabolite dextrophan (DX) were
assayed by HPLC and metabolic ratios (MR) were calculated in 120 unrelated native
Chinese subjects after ingestion of DM 20 mg.
RESULTS: The incidence of poor metabolizers was 0.8% (one in 120 subjects). There
were distinct dimodal distributions which divided extensive metabolizers into 43
intermediate metabolizers and 76 very extensive metabolizers. The 0-8 h urinary
recoveries of DM and DX were 0.4% +/- s 0.5% and 26% +/- s 13%, respectively.
There was no difference in 0-8 h urinary recoveries between male and female
subjects.
CONCLUSION: DM metabolic phenotyping provides a new information for debrisoquine
4-hydroxylation (CYP2D6) polymorphism in native Chinese.