Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats
Abstract
AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension.
METHODS: An ""inflammatory"" chronic pulmonary hypertension induced by
monocrotaline (Mon) in rats was used.
RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced
increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and
42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05)
respectively compared with those from Mon group, without significant influence on
the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic
stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for
3 wk, inhibited the increase of medial thickness and cross sectional area by
57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group.
CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue
injury induced by Mon in rats.
Keywords:
METHODS: An ""inflammatory"" chronic pulmonary hypertension induced by
monocrotaline (Mon) in rats was used.
RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced
increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and
42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05)
respectively compared with those from Mon group, without significant influence on
the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic
stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for
3 wk, inhibited the increase of medial thickness and cross sectional area by
57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group.
CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue
injury induced by Mon in rats.