Effects of fructus cnidii coumarins compared with nilestriol on osteoporosis in ovariectomized rats
Abstract
AIM: To compare the total coumarins from dried fruits of Cnidium monnieri (TCCM)
and nilestriol (Nil) against osteoporosis.
METHODS: SD rats (40, female, 3-month-old) were randomly divided into basal
control, age control, ovariectomized (Ova), Ova + TCCM 67 mg.kg-1, Ova + TCCM 200
mg.kg-1, 6 times a week, and Ova + Nil 1 mg.kg-1, i.g. once a week. After 12 wk,
sections (20 microns) of proximal tibiae were examined histologically.
RESULTS: Ova reduced markedly the trabecular bone mass due to bone resorption
excessed bone formation (% Tb. Ar -59%). Treatment with TCCM 67 mg.kg-1 partly
suppressed bone turnover, but did not inhibit bone loss in Ova rats (% Tb.Ar
-43%). Treatment with TCCM 200 mg.kg-1 and Nil 1 mg.kg-1 increased the trabecular
area (% Tb. Ar +100% and +274%).
CONCLUSION: Nil was more potent than TCCM in protecting against osteoporosis in
Ova rats via supression of bone turnover.
Keywords:
and nilestriol (Nil) against osteoporosis.
METHODS: SD rats (40, female, 3-month-old) were randomly divided into basal
control, age control, ovariectomized (Ova), Ova + TCCM 67 mg.kg-1, Ova + TCCM 200
mg.kg-1, 6 times a week, and Ova + Nil 1 mg.kg-1, i.g. once a week. After 12 wk,
sections (20 microns) of proximal tibiae were examined histologically.
RESULTS: Ova reduced markedly the trabecular bone mass due to bone resorption
excessed bone formation (% Tb. Ar -59%). Treatment with TCCM 67 mg.kg-1 partly
suppressed bone turnover, but did not inhibit bone loss in Ova rats (% Tb.Ar
-43%). Treatment with TCCM 200 mg.kg-1 and Nil 1 mg.kg-1 increased the trabecular
area (% Tb. Ar +100% and +274%).
CONCLUSION: Nil was more potent than TCCM in protecting against osteoporosis in
Ova rats via supression of bone turnover.