Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis
Abstract
AIM: To study the antipsoriatic, anti-inflammatory, and analgesic effects of
ethanolic extract of red propolis.
METHODS AND RESULTS: This extract induced the formation of granular layer in the
mouse tail test used as a model of psoriasis. Propolis 50 mg.kg-1 i.g. showed
anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in
croton oil-induced edema in mice at a dose of 25% (2.5 microL), and in the
peritoneal capillary permeability test in mice at a dose of 10 mg.kg-1. The
extract (25 mg.kg-1 i.g.) showed analgesic effect in the model of acetic
acid-induced writhings, whereas 40 mg.kg-1 was effective in the hot plate test in
mice.
CONCLUSION: Anti-inflammatory, analgesic, and antipsoriatric properties of Cuban
red propolis were evident.
Keywords:
ethanolic extract of red propolis.
METHODS AND RESULTS: This extract induced the formation of granular layer in the
mouse tail test used as a model of psoriasis. Propolis 50 mg.kg-1 i.g. showed
anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in
croton oil-induced edema in mice at a dose of 25% (2.5 microL), and in the
peritoneal capillary permeability test in mice at a dose of 10 mg.kg-1. The
extract (25 mg.kg-1 i.g.) showed analgesic effect in the model of acetic
acid-induced writhings, whereas 40 mg.kg-1 was effective in the hot plate test in
mice.
CONCLUSION: Anti-inflammatory, analgesic, and antipsoriatric properties of Cuban
red propolis were evident.