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Castration reverses immunosenescence in aged mice

Shang-xue Yan, Wei Wei
DOI: 10.1038/aps.2011.110

Abstract

The increasing aged population poses new challenges to healthcare systems. The elderly frequently suffers from severe infections and end-stage organ disease, which are associated with an age-dependent decline in immune reactivity (1, 2). Immunosenescence, defined as the changes in the immune system associated with age, is gathering interest in the scientific and healthcare communities alike.
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