Genetic polymorphism of 4'-hydroxylation of S-mephenytoin in 148 Chinese of Han nationality
Abstract
AIM:
To study genetic polymorphism of S-mephenytoin (S-Mep) 4'-hydroxylation in the Chinese population of Han nationality.
METHODS:
The lg metabolic ratio (MR) and lg hydroxylation index (HI) in the urine (0-12 h) after oral administration with 100 mg of racemic Mep tablet were determined by HPLC method in 148 consangeously unrelated native Chinese subjects and 21 individuals of 5 families.
RESULTS:
The lg MR and lg HI showed a bimodal distribution with an antimode of -1.00 and 1.50, respectively. The occurrence of poor metabolizers (PM) was 13.5% in the population. The pedigree analysis in 5 families indicated that deficient S-Mep hydroxylation was an autosomal recessive trait.
CONCLUSIONS:
The occurrence of PM for S-Mep 4-hydroxylation in Chinese was higher than that of the Caucasians, and both genetic modes were of autosomal recessive trait.
Keywords:
To study genetic polymorphism of S-mephenytoin (S-Mep) 4'-hydroxylation in the Chinese population of Han nationality.
METHODS:
The lg metabolic ratio (MR) and lg hydroxylation index (HI) in the urine (0-12 h) after oral administration with 100 mg of racemic Mep tablet were determined by HPLC method in 148 consangeously unrelated native Chinese subjects and 21 individuals of 5 families.
RESULTS:
The lg MR and lg HI showed a bimodal distribution with an antimode of -1.00 and 1.50, respectively. The occurrence of poor metabolizers (PM) was 13.5% in the population. The pedigree analysis in 5 families indicated that deficient S-Mep hydroxylation was an autosomal recessive trait.
CONCLUSIONS:
The occurrence of PM for S-Mep 4-hydroxylation in Chinese was higher than that of the Caucasians, and both genetic modes were of autosomal recessive trait.